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The protective effects of melatonin against water avoidance stress-induced mast cell degranulation in dermis

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dc.contributor.authorERCAN, FERİHA
dc.contributor.authorsCikler, E; Ercan, F; Cetinel, S; Contuk, G; Sener, G
dc.date.accessioned2022-03-12T17:19:09Z
dc.date.available2022-03-12T17:19:09Z
dc.date.issued2005
dc.description.abstractNontraumatic psychological water avoidance stress has been shown to induce mucosal. degeneration, inflammatory cell infiltration and mast cell degranulation in stomach, ileum, colon and urinary bladder. Many skin disorders, such as atopic dermatitis and psoriasis, worsen during stress and seem to be related with infiltration and activation of mast cells releasing vasoactive and proinflammatory mediators. Melatonin is a free radical scavenger and has cytoprotective effects in inflammatory conditions. The aim of the present study was to investigate the effects of melatonin on water avoidance stress (WAS)-induced degranulation of mast cells in the dermis. Wistar rats were exposed to acute WAS (aWAS group) or chronic WAS (cWAS group). Before exposing to acute WAS, one group of animals was treated with 10mg/kg metatonin (aWAS+mel. group). In the cWAS+mel group, treatment with melatonin lasted for 5 days. Dermal mast cells were stained with toluidine blue and investigated using light microscopy. Numbers of mast cells were increased in both aWAS and cWAS groups, but numbers of degranulated mast cells were increased significantly only in the cWAS group when compared to the control group. Numbers of mature granulated and degranulated mast cells were decreased in the cWAS+mel. group when compared to the cWAS group. In conclusion, chronic metatonin treatment reduced WAS-induced infiltration and activation of mast cells in dermis and may provide a useful therapeutic option in stress-induced skin disorders. (c) 2004 Elsevier GmbH. All rights reserved.
dc.identifier.doi10.1016/j.acthis.2004.10.001
dc.identifier.eissn1618-0372
dc.identifier.issn0065-1281
dc.identifier.pubmed15707656
dc.identifier.urihttps://hdl.handle.net/11424/228065
dc.identifier.wosWOS:000227722700008
dc.language.isoeng
dc.publisherELSEVIER GMBH
dc.relation.ispartofACTA HISTOCHEMICA
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectwater avoidance stress
dc.subjectmast cells
dc.subjectdegranulation
dc.subjectmelatonin
dc.subjectCORTICOTROPIN-RELEASING HORMONE
dc.subjectPITUITARY-ADRENAL AXIS
dc.subjectVASCULAR-PERMEABILITY
dc.subjectSUBSTANCE-P
dc.subjectSKIN
dc.subjectRAT
dc.subjectNEUROTENSIN
dc.subjectSECRETION
dc.subjectINFLAMMATION
dc.subjectNEURONS
dc.titleThe protective effects of melatonin against water avoidance stress-induced mast cell degranulation in dermis
dc.typearticle
dspace.entity.typePublication
local.avesis.id7a390609-1e36-4c29-a690-e9d47f5bdf2e
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages9
oaire.citation.endPage475
oaire.citation.issue6
oaire.citation.startPage467
oaire.citation.titleACTA HISTOCHEMICA
oaire.citation.volume106
relation.isAuthorOfPublicationadc800ed-105c-40c7-a572-6cf3f175be92
relation.isAuthorOfPublication.latestForDiscoveryadc800ed-105c-40c7-a572-6cf3f175be92

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