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The association of urinary BDNF, ATP, and MMP-2 with bladder compliance in children with myelodysplasia

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dc.contributor.authorŞEKERCİ, ÇAĞRI AKIN
dc.contributor.authorKÜTÜKOĞLU, MEHMET UMUT
dc.contributor.authorYÜCEL, SELÇUK
dc.contributor.authorTARCAN, TUFAN
dc.contributor.authorsŞEKERCİ Ç. A., KÜTÜKOĞLU M. U., Basok B. I., Fidan M., ÇAM S., YÜCEL S., TARCAN T.
dc.date.accessioned2023-09-12T13:21:52Z
dc.date.available2023-09-12T13:21:52Z
dc.date.issued2023-01-01
dc.description.abstractAim: The purpose of our study was to evaluate the relationship of urinary brain-derived neurotrophic factor (BDNF), adenosine triphosphate (ATP), matrix metallopreteinase-2 (MMP-2) with urodynamic findings and upper urinary tract deterioration (UUTD) in children with myelodysplasia. Materials and Methods: Children with myelodysplasia evaluated in outpatient clinic between 2022 and 2023 were included. All patients underwent urinary ultrasonography, voiding cystourethrography, urodynamics, and DMSA scintigraphy. Urine samples were collected before urodynamics. Control urine was collected from 10 healthy children. Urinary biomarker values of patients and controls were compared, and subgroup analysis was performed. Results: The median age of 40 children (26 girls) included in the study was 108 (8–216) months, and the control group (six girls) was 120 (60–154) (p = 0.981). Urinary BDNF, MMP-2, and ATP were found to be significantly higher in children with myelodysplasia compared to the control (p = 0.007, p = 0.027, p = 0.014, respectively). The three biomarker values were similar in children with bladder compliance below or above 10 cmH2O/mL (p = 0.750, p = 0.844, p = 0.575). No difference was found in terms of UUTD in all three biomarkers (p = 0.387, p = 0.892, p = 0.705). A negative correlation was found between urinary ATP and compliance (p < 0.05). Conclusion: In this study, all three biomarkers were found to be higher in children with myelodysplasia than in controls. There was a negative correlation between urinary ATP and compliance. Urinary biomarkers may contribute the follow-up of children with neurogenic lower urinary tract deterioration in future with their noninvasive features. However, the lack of standardization and the inability to reliably predict risky groups are important shortcomings of urinary biomarkers.
dc.identifier.citationŞEKERCİ Ç. A., KÜTÜKOĞLU M. U., Basok B. I., Fidan M., ÇAM S., YÜCEL S., TARCAN T., "The association of urinary BDNF, ATP, and MMP-2 with bladder compliance in children with myelodysplasia", Neurourology and Urodynamics, 2023
dc.identifier.doi10.1002/nau.25269
dc.identifier.issn0733-2467
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85168588116&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/293269
dc.language.isoeng
dc.relation.ispartofNeurourology and Urodynamics
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectNefroloji
dc.subjectNöroloji
dc.subjectSağlık Bilimleri
dc.subjectMedicine
dc.subjectInternal Medicine Sciences
dc.subjectInternal Diseases
dc.subjectNephrology
dc.subjectNeurology
dc.subjectHealth Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectÜROLOJİ VE NEFROLOJİ
dc.subjectKLİNİK NÖROLOJİ
dc.subjectClinical Medicine (MED)
dc.subjectCLINICAL MEDICINE
dc.subjectUROLOGY & NEPHROLOGY
dc.subjectCLINICAL NEUROLOGY
dc.subjectNöroloji (klinik)
dc.subjectÜroloji
dc.subjectNeurology (clinical)
dc.subjectUrology
dc.subjectATP
dc.subjectBDNF
dc.subjectchildren
dc.subjectMMP-2
dc.subjectmyelodisplasia
dc.subjecturodynamics
dc.titleThe association of urinary BDNF, ATP, and MMP-2 with bladder compliance in children with myelodysplasia
dc.typearticle
dspace.entity.typePublication
local.avesis.id4a258c92-1ae0-422e-9afb-06bcc7f9c23d
local.indexed.atPUBMED
local.indexed.atSCOPUS
local.indexed.atWOS
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relation.isAuthorOfPublication.latestForDiscovery1e489bdb-418e-4500-a522-6c0babb604b9

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