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Effect of inhaled steroids on clinical and inflammatory parameters in children with cystic fibrosis

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dc.contributor.authorKARADAĞ, BÜLENT TANER
dc.contributor.authorsUyan, Zeynep Seda; Unluguzel Ustun, Goksenin; Haklar, Goncagul; Cakir, Erkan; Oktem, Sedat; Ersu, Refika; Karadag, Bulent Taner; Karakoc, Fazilet; Dagli, Elif
dc.date.accessioned2022-04-25T00:11:05Z
dc.date.available2022-04-25T00:11:05Z
dc.date.issued2017
dc.description.abstractBackground/aim: The effectiveness of inhaled corticosteroids (ICSs) in cystic fibrosis (CF) is controversial. The aim of this study was to investigate the effect of an ICS on bronchial hyperreactivity (BHR), oxidative status, and clinical and inflammatory parameters in CF patients. Materials and methods: CF patients were randomized to receive either 2 mg/day nebulized budesonide or 0.9% normal saline as placebo for 8 weeks. Results: Twenty-nine CF patients (mean age: 10.5 +/- 2.9 years) were enrolled in the study. There was no statistically significant difference between the two groups at the end of 8 weeks in terms of symptoms, pulmonary function, BHR, oxidative burst, hs-CRP, or ESR. Although there was a significant decrease in malondialdehyde levels in both groups, there was no difference between the two groups. Percentage of neutrophils in the sputum of patients decreased in the budesonide group (P = 0.006). Although sputum IL-8 levels significantly increased in both groups, there was no statistically significant difference between the two groups. Conclusion: Although there was a significant decrease in the percentage of neutrophils in sputum with budesonide, 8 weeks of 2 mg/day nebulized budesonide was not effective in terms of BHR, oxidative status, or clinical and other inflammatory parameters in children with CF.
dc.identifier.doi10.3906/sag-1509-101
dc.identifier.eissn1303-6165
dc.identifier.issn1300-0144
dc.identifier.pubmed29151314
dc.identifier.urihttps://hdl.handle.net/11424/263834
dc.identifier.wosWOS:000414976900018
dc.languageeng
dc.publisherTUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY
dc.relation.ispartofTURKISH JOURNAL OF MEDICAL SCIENCES
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntiinflammatory treatment
dc.subjectchildren
dc.subjectcystic fibrosis
dc.subjectglucocorticoids
dc.subjectinhalation
dc.subjectRANDOMIZED CONTROLLED-TRIAL
dc.subjectLUNG-FUNCTION DECLINE
dc.subjectFLUTICASONE PROPIONATE
dc.subjectANTIINFLAMMATORY THERAPIES
dc.subjectAIRWAY INFLAMMATION
dc.subjectYOUNG-CHILDREN
dc.subjectLONG-TERM
dc.subjectCORTICOSTEROIDS
dc.subjectSPUTUM
dc.subjectMETHACHOLINE
dc.titleEffect of inhaled steroids on clinical and inflammatory parameters in children with cystic fibrosis
dc.typearticle
dspace.entity.typePublication
local.avesis.id977e7b35-1eb8-4170-99ff-cf94568b7cb5
local.import.packageSS39
local.indexed.atWOS
local.journal.numberofpages9
local.journal.quartileQ4
oaire.citation.endPage1440
oaire.citation.issue5
oaire.citation.startPage1432
oaire.citation.titleTURKISH JOURNAL OF MEDICAL SCIENCES
oaire.citation.volume47
relation.isAuthorOfPublication218b489d-97ab-49dd-9db6-0c2a732f1999
relation.isAuthorOfPublication.latestForDiscovery218b489d-97ab-49dd-9db6-0c2a732f1999

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