Publication:
Screening of Antimicrobial Activity and Cytotoxic Effects of Two Cladonia Species

Simple item page
dc.contributor.authorsAcikgoz, Birkan; Karalti, Iskender; Ersoz, Melike; Coskun, Zeynep M.; Cobanoglu, Gulsah; Sesal, Cenk
dc.date.accessioned2022-03-12T18:10:20Z
dc.date.available2022-03-12T18:10:20Z
dc.date.issued2013
dc.description.abstractThe present study explores the antimicrobial activity and cytotoxic effects in culture assays of two fruticose soil lichens, Cladonia rangiformis Hoffm. and Cladonia convoluta (Lamkey) Cout., to contribute to possible pharmacological uses of lichens. In vitro antimicrobial activities of methanol and chloroform extracts against two Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli), two Gram-positive bacteria (Enterococcus faecalis and Staphylococcus aureus), and the yeast Candida albicans were examined using the paper disc method and through determination of minimal inhibitory concentrations (MICs). The data showed the presence of antibiotic substances in the chloroform and the methanol extracts of the lichen species. The chloroform extracts exhibited more significant antimicrobial activity than the methanol extracts. However, a higher antifungal activity was noted in the methanol extract of C. rangiformis. The maximum antimicrobial activity was recorded for the chloroform extract of C. convoluta against E. coli. The cytotoxic effects of the lichen extracts on human breast cancer MCF-7 cells were evaluated by the trypan blue assay yielding IC50 values of ca. 173 and 167 mu g/ml for the extracts from C. rangiformis and C. convoluta, respectively.
dc.identifier.doidoiWOS:000323864600004
dc.identifier.eissn1865-7125
dc.identifier.issn0939-5075
dc.identifier.pubmed23923615
dc.identifier.urihttps://hdl.handle.net/11424/231373
dc.identifier.wosWOS:000323864600004
dc.language.isoeng
dc.publisherWALTER DE GRUYTER GMBH
dc.relation.ispartofZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectLichen
dc.subjectAntimicrobial Activity
dc.subjectMCF-7
dc.subjectCladonia
dc.subjectLICHEN EXTRACTS
dc.subject(-)-USNIC ACID
dc.subjectANTIOXIDANT
dc.subjectANTIFUNGAL
dc.subjectFOLIACEA
dc.titleScreening of Antimicrobial Activity and Cytotoxic Effects of Two Cladonia Species
dc.typearticle
dspace.entity.typePublication
local.avesis.id3bfdffb4-cf91-49bd-9a1c-36ea47df2ba2
local.import.packageSS17
local.indexed.atWOS
local.journal.numberofpages7
oaire.citation.endPage197
oaire.citation.issue5-6
oaire.citation.startPage191
oaire.citation.titleZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
oaire.citation.volume68

Files

Collections

Research Outputs