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In vitro contractile responses of human detrusor smooth muscle to oxytocin: does it really have effect?

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dc.contributor.authorKARAALP, ATİLA
dc.contributor.authorsTarhan, Fatih; Duman, Nesrin Caglayan; Ozkula, Songul; Karaalp, Atila; Canguven, Onder
dc.date.accessioned2022-03-12T22:44:27Z
dc.date.available2022-03-12T22:44:27Z
dc.date.issued2020
dc.description.abstractBackground and objectives: The aim of this study was to investigate the contractile effects of oxytocin (OT) in human detrusor muscle in in vitro conditions. Material and Methods: Human detrusor muscle samples were obtained from seven patients that undergone radical cystectomy. Four female Wistar rats' uterine samples were used as control. Contractile responses were tested of carbachol in organ bath. Cumulative concentration response curves were constructed to OT and then the strips were incubated with atosiban (OT antagonist) and a second concentration response curve to OT were constructed. Results: Carbachol, contracted all human strips for the functionality test whereas OT in any concentrations did not produce significant contraction on all human strips. In only one bladder strip and in a very high concentration slight contraction was recorded. Moreover no contractile response was recorded in any OT concentrations in the presence of atosiban. The rat uterine strips responded to OT in a dose dependent manner. Atosiban, the OT receptor antagonist diminished totally those contractile responses. Conclusion: It is been demonstrated here that there is no contractile response to OT in human detrusor muscle. These findings should be supported by further investigations determining the presence of the OT receptor in human detrusor.
dc.identifier.doi10.1080/13685538.2020.1711722
dc.identifier.eissn1473-0790
dc.identifier.issn1368-5538
dc.identifier.pubmed31910704
dc.identifier.urihttps://hdl.handle.net/11424/236432
dc.identifier.wosWOS:000506120200001
dc.language.isoeng
dc.publisherTAYLOR & FRANCIS LTD
dc.relation.ispartofAGING MALE
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAtosiban
dc.subjectoxytocin
dc.subjecthuman
dc.subjectIn Vitro
dc.subjecturinary bladder
dc.subjectRECEPTOR
dc.subjectBLADDER
dc.titleIn vitro contractile responses of human detrusor smooth muscle to oxytocin: does it really have effect?
dc.typearticle
dspace.entity.typePublication
local.avesis.id766bd594-46fe-4496-a3a5-a19e486d7e90
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages5
local.journal.quartileQ1
oaire.citation.endPage1145
oaire.citation.issue5
oaire.citation.startPage1141
oaire.citation.titleAGING MALE
oaire.citation.volume23
relation.isAuthorOfPublicationf69f1d1c-df19-4b9c-9d29-a8d3882bae38
relation.isAuthorOfPublication.latestForDiscoveryf69f1d1c-df19-4b9c-9d29-a8d3882bae38

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