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Bacterial cellulose tubes as a nerve conduit for repairing complete facial nerve transection in a rat model

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dc.contributor.authorBİNNETOĞLU, ADEM
dc.contributor.authorsBinnetoglu, Adem; Demir, Berat; Akakin, Dilek; Demirci, Elif Kervancioglu; Batman, Caglar
dc.date.accessioned2022-03-12T22:44:28Z
dc.date.available2022-03-12T22:44:28Z
dc.date.issued2020
dc.description.abstractPurpose Functionality of the facial nerve is cosmetically important. While many techniques have been investigated, early and effective treatment for traumatic facial nerve paralysis remains challenging. Here, we aim to examine bacterial cellulose (BC) as a new tubularization material for improving facial nerve regeneration. Methods Our study was performed on 40 female Sprague Dawley rats. Rats were randomly divided into four groups, with 10 rats per group. In all rats, the main trunk of the facial nerve was completely cut 8 mm before the branching point. For repairing the facial nerve, in group 1, the nerve was left to recover spontaneously (control group); in group 2, it was repaired by primary suturing (8.0 Ethilon sutures, Ethicon); in group 3, BC tubes alone were used to aid nerve repair; and in group 4, both BC tubes and primary sutures (8.0 Ethilon sutures) were used. After 10 weeks, the facial nerve regeneration was evaluated by the whisker movement test and electrophysiologically (nerve stimulation threshold and compound muscle action potential). Nerve regeneration was assessed by calculating the number of myelinated nerve fibers, and by microscopically evaluating the amount of regeneration and fibrosis. Results No significant difference was observed among the groups in terms of whisker movement and electrophysiological parameters (P > 0.05). We found that the numbers of regenerating myelinated fibers were significantly increased (P < 0.05) when BC tubes were used as a nerve conduit. Conclusions BC can be easily shaped into a hollow tube that guides nerve axons, resulting in better nerve regeneration after transection.
dc.identifier.doi10.1007/s00405-019-05637-9
dc.identifier.eissn1434-4726
dc.identifier.issn0937-4477
dc.identifier.pubmed31595316
dc.identifier.urihttps://hdl.handle.net/11424/236433
dc.identifier.wosWOS:000511653200035
dc.language.isoeng
dc.publisherSPRINGER
dc.relation.ispartofEUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectFacial nerve
dc.subjectPeripheral nerve trauma
dc.subjectNeurotmesis
dc.subjectBacterial cellulose
dc.subjectTubularization
dc.subjectREGENERATION
dc.subjectMANAGEMENT
dc.subjectSURGERY
dc.subjectTISSUE
dc.subjectGRAFT
dc.titleBacterial cellulose tubes as a nerve conduit for repairing complete facial nerve transection in a rat model
dc.typearticle
dspace.entity.typePublication
local.avesis.idd7fa0262-a935-4c21-b301-f2a3181a5259
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages7
local.journal.quartileQ2
oaire.citation.endPage283
oaire.citation.issue1
oaire.citation.startPage277
oaire.citation.titleEUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
oaire.citation.volume277
relation.isAuthorOfPublication7d22b68b-082d-4ffc-95cf-2646bb131363
relation.isAuthorOfPublication.latestForDiscovery7d22b68b-082d-4ffc-95cf-2646bb131363

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