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The effect of central sensitization on interlaminar epidural steroid injection treatment outcomes in patients with cervical disc herniation: an observational study

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dc.contributor.authorSAÇAKLIDIR, REKİB
dc.contributor.authorŞANAL TOPRAK, CANAN
dc.contributor.authorGÜNDÜZ, OSMAN HAKAN
dc.contributor.authorŞENCAN, SAVAŞ
dc.contributor.authorsSacaklidir R., ŞANAL TOPRAK C., Yucel F. N. , GÜNDÜZ O. H. , ŞENCAN S.
dc.date.accessioned2022-12-23T08:52:22Z
dc.date.available2022-12-23T08:52:22Z
dc.date.issued2022-09-01
dc.description.abstract© 2022, American Society of Interventional Pain Physicians. All rights reserved.Background: Central sensitization (CS) is a hyperexcitability that is manifested by the increased response of the central nervous system to sensory stimuli. It has been shown that the presence of CS may have a negative effect on the clinical picture in some musculoskeletal diseases and also have a negative effect on spinal procedures. Objectives: To investigate the effect of CS on interlaminar epidural steroid injection (ILESI) treatment outcomes in patients with cervical disc herniation (CDH). Study Design: An observational study. Setting: A university hospital pain management center. Methods: Patients, who underwent ILESI between 2020-2021 due to CDH, were included in the study. The Numeric Rating Scale (NRS-11), Neck Pain and Disability Scale (NPDS), Self-Administered Leeds Assessment of Neuropathic Symptoms and Signs (S-LANSS), and Short Form-12 (SF-12) were used for evaluation of patients. Patients were assessed before the procedure, at the first hour, and 3 months after the procedure. The presence of CS was investigated by the Central Sensitization Inventory (CSI). Results: A total of 51 patients were included in the study. Twenty-three of the patients had CS, as assessed by the CSI. Although, patients who underwent ESI, had significantly lower NRS-11, S-LANSS, and NPDS scores, and higher SF-12 scores at all follow-up points. The first and third months, NRS-11, S-LANSS, and NPDS were significantly higher, and SF-12 scores were lower in the CS group compared to patients without CS. Limitations: The short follow-up period and relatively low number of patients can be considered as a limitation. The fact that CS is not evaluated with a more objective method, such as Quantitative Sensory Testing (QST), can be considered as another limitation. Since most clinicians use CSI, so from a \"real world\" perspective the lack of QST may be observed as a strength of the study. The third limitation is that we did not evaluate the patients’ pre-and posttreatment analgesic consumption. Finally, we did not include patients with a history of psychiatric illness, but not evaluating the current psychiatric conditions of the patients could be considered a limitation. Nevertheless, the main strengths of this study are its prospective design and, to our knowledge, it is the first study to explore the effects of CS on cervical ESI treatment. Conclusions: The presence of CS has a negative effect on pain scores, disability, and quality of life in patients undergoing cervical ESI due to CDH.
dc.identifier.citationSacaklidir R., ŞANAL TOPRAK C., Yucel F. N. , GÜNDÜZ O. H. , ŞENCAN S., "The Effect of Central Sensitization on Interlaminar Epidural Steroid Injection Treatment Outcomes in Patients with Cervical Disc Herniation: An Observational Study", Pain Physician, cilt.25, sa.6, 2022
dc.identifier.endpage829
dc.identifier.issn1533-3159
dc.identifier.issue6
dc.identifier.startpage823
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85138129961&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/283882
dc.identifier.volume25
dc.language.isoeng
dc.relation.ispartofPain Physician
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectCerrahi Tıp Bilimleri
dc.subjectAnesteziyoloji
dc.subjectSağlık Bilimleri
dc.subjectMedicine
dc.subjectSurgery Medicine Sciences
dc.subjectAnesthesiology
dc.subjectHealth Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectANESTEZİYOLOJİ
dc.subjectClinical Medicine (MED)
dc.subjectCLINICAL MEDICINE
dc.subjectANESTHESIOLOGY
dc.subjectAnesteziyoloji ve Ağrı Tıbbı
dc.subjectAnesthesiology and Pain Medicine
dc.subjectcentral sensitization
dc.subjectcentral sensitization inventory
dc.subjectCervical disc herniation
dc.subjectepidural injections
dc.subjectinterlaminar
dc.subjectneck pain
dc.subjectsteroids
dc.subjecttreatment success
dc.subjectCervical disc herniation
dc.subjectepidural injections
dc.subjectcentral sensitization
dc.subjectcentral sensitization inventory
dc.subjectneck pain
dc.subjecttreatment success
dc.subjectinterlaminar
dc.subjectsteroids
dc.titleThe effect of central sensitization on interlaminar epidural steroid injection treatment outcomes in patients with cervical disc herniation: an observational study
dc.typearticle
dspace.entity.typePublication
local.avesis.id9f14aac7-f1af-4dc3-929e-19cff1440642
local.indexed.atPUBMED
local.indexed.atSCOPUS
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relation.isAuthorOfPublication.latestForDiscovery8d87dcc0-80e3-4393-96af-4790ce1ceb29

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