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Evaluation of Genotoxicity Risk in Health Care Workers Exposed to Antineoplastic Drugs

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dc.contributor.authorBECEREN, AYFER
dc.contributor.authorsOltulu, Cagatay; Yesil Devecioglu, Tugce; Akinci, Melek; Olmez, Sevcan Gul Akgun; Obeidin, Serra Vildan Akgul; Beceren, Ayfer
dc.date.accessioned2022-03-14T09:14:27Z
dc.date.available2022-03-14T09:14:27Z
dc.date.issued2019-06-30
dc.description.abstractObjective: DNA damage that can be caused by workplace exposure to antineoplastic drugs in health workers has been shown in many scientific studies. It is aimed to evaluate whether the risk of genotoxicity in health workers decreases after the regulations and measures taken by national and international health authorities in our work. Methods: For this purpose, DNA damage was assessed by using alkaline comet technique in lymphocytes isolated from blood samples of health workers (n=29) who were involved in preparing and/or administering antineoplastic agent at Trakya University Health Research and Application Center and compared with the control group (n=30). Also, those who prepare and/or administer antineoplastic agents; (n=16) and manual (n=13) preparations. Results: As a result of the evaluation, there was no statistically significant difference between health personnel and control group in preparing and / or administering antineoplastic agent (p>0,05, Mann-Whitney U) and there was no difference in the genotoxic risk between preparation forms. Furthermore, when the exposed control group was assessed for DNA damage as smokers and nonsmokers, there was no statistically significant difference in terms of DNA damage (p>0.05). Conclusion: At the center where our samples were taken, the resulting measures resulted in the control of the risk of genotoxicity due to occupational exposure to antineoplastic agents.
dc.identifier.doi10.33808/clinexphealthsci.563988
dc.identifier.issn2459-1459
dc.identifier.urihttps://hdl.handle.net/11424/242832
dc.identifier.wosWOS:000473218600012
dc.language.isoeng
dc.publisherMARMARA UNIV, INST HEALTH SCIENCES
dc.relation.ispartofCLINICAL AND EXPERIMENTAL HEALTH SCIENCES
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAlkaline Comet Assay
dc.subjectGenotoxicity
dc.subjectAntineoplastic
dc.subjectOccupational exposure
dc.subjectOccupational health safety
dc.subjectDNA-DAMAGE
dc.subjectCOMET ASSAY
dc.subjectNURSES
dc.subjectCONTAMINATION
dc.subjectLYMPHOCYTES
dc.subjectASSOCIATION
dc.subjectENVIRONMENT
dc.subjectPOPULATION
dc.subjectREPAIR
dc.titleEvaluation of Genotoxicity Risk in Health Care Workers Exposed to Antineoplastic Drugs
dc.typearticle
dspace.entity.typePublication
local.avesis.idcefc8e72-7b04-4c32-917b-1cbd292c09a1
local.import.packageSS16
local.indexed.atWOS
local.indexed.atTRDIZIN
local.journal.numberofpages5
oaire.citation.endPage170
oaire.citation.issue2
oaire.citation.startPage166
oaire.citation.titleCLINICAL AND EXPERIMENTAL HEALTH SCIENCES
oaire.citation.volume9
relation.isAuthorOfPublication759fae37-2af1-47e6-92f8-545c02df272b
relation.isAuthorOfPublication.latestForDiscovery759fae37-2af1-47e6-92f8-545c02df272b

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