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Resveratrol protects against irradiation-induced hepatic and ileal damage via its anti-oxidative activity

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dc.contributor.authorVELİOĞLU ÖĞÜNÇ, AYLİZ
dc.contributor.authorsVelioglu-Ogunc, Ayliz; Sehirli, Ozer; Toklu, Hale Z.; Ozyurt, Hazan; Mayadagli, Alpaslan; Eksioglu-Demiralp, Emel; Erzik, Can; Cetinel, Sule; Yegen, Berrak C.; Sener, Goeksel
dc.date.accessioned2022-03-12T17:46:40Z
dc.date.available2022-03-12T17:46:40Z
dc.date.issued2009
dc.description.abstractThe present study was undertaken to determine whether resveratrol (RVT) could ameliorate ionizing radiation-induced oxidative injury. After a 10-days pre-treatment with RVT (10 mg/kg/day p.o.), rats were exposed to whole-body IR (800 cGy) and the RVT treatment was continued for 10 more days after the irradiation. Irradiation caused a significant decrease in glutathione level, while malondialdehyde levels, myeloperoxidase activity and collagen content were increased in the liver and ileum tissues. Similarly, plasma lactate dehydrogenase and pro-inflammatory cytokine levels, 8-hydroxy-2'-deoxyguanosine and leukocyte apoptosis were elevated, while antioxidant-capacity was reduced in the irradiated rats as compared with the control group. Furthermore, Na-1, K-1 -ATPase activity was inhibited and DNA fragmentation was increased in the ileal tissues. Resveratrol treatment reversed all these biochemical indices, as well as histopathological alterations induced by irradiation. In conclusion, supplementing cancer patients with adjuvant therapy of resveratrol may have some benefit for a more successful radiotherapy.
dc.identifier.doi10.1080/10715760903171100
dc.identifier.eissn1029-2470
dc.identifier.issn1071-5762
dc.identifier.pubmed19707923
dc.identifier.urihttps://hdl.handle.net/11424/229498
dc.identifier.wosWOS:000270212000002
dc.language.isoeng
dc.publisherTAYLOR & FRANCIS LTD
dc.relation.ispartofFREE RADICAL RESEARCH
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectIrradiation
dc.subjectlipid peroxidation
dc.subjectglutathione
dc.subjectmyeloperoxidase
dc.subjectresveratrol
dc.subjectINDUCED OXIDATIVE STRESS
dc.subjectINDUCED LUNG INJURY
dc.subjectIONIZING-RADIATION
dc.subjectRED WINE
dc.subjectRATS
dc.subjectMECHANISM
dc.subjectCANCER
dc.subjectCELLS
dc.subjectORGAN
dc.subjectACID
dc.titleResveratrol protects against irradiation-induced hepatic and ileal damage via its anti-oxidative activity
dc.typearticle
dspace.entity.typePublication
local.avesis.id64ecf790-f8cf-4b10-bb27-3aaf00534c9f
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages12
oaire.citation.endPage1071
oaire.citation.issue11
oaire.citation.startPage1060
oaire.citation.titleFREE RADICAL RESEARCH
oaire.citation.volume43
relation.isAuthorOfPublication13300bf6-ba96-4f87-9868-b0d2c86f572a
relation.isAuthorOfPublication.latestForDiscovery13300bf6-ba96-4f87-9868-b0d2c86f572a

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