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Epicardial adipose tissue thickness in type 1 diabetic patients

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dc.contributor.authorÖZBEN SADIÇ, BESTE
dc.contributor.authorsYazici, Dilek; Ozben, Beste; Yavuz, Dilek; Deyneli, Oguzhan; Aydin, Hasan; Tarcin, Ozlem; Akalin, Sema
dc.date.accessioned2022-03-12T17:50:57Z
dc.date.available2022-03-12T17:50:57Z
dc.date.issued2011
dc.description.abstractInsulin resistance is getting important in the course of type 1 diabetes mellitus. Visceral fat depot is associated with insulin resistance and assessment of epicardial fat thickness is a way of measuring visceral fat. The aim of the study was to measure epicardial adipose tissue (EAT) thickness and to determine its relationship with waist-hip-ratio (WHR) and estimated glucose disposal rate (eGDR) in adult type 1 diabetic patients. Thirty-six type 1 diabetic patients (aged 31 +/- 8 years; Female/Male: 22/14) and 43 age, gender and BMI matched healthy controls were included. Fasting blood glucose (FBG), hemoglobin A1c, and lipid profiles were measured. Waist-hip-ratio (WHR) was calculated. Daily insulin dose/kg of patients were recorded and eGDR of all subjects was calculated. Epicardial adipose tissue (EAT) thickness was evaluated by echocardiography. EAT thickness of the type 1 diabetic patients was significantly higher than controls (3.30 +/- 1.06 vs. 2.30 +/- 0.34 mm, P < 0.0001). EAT thickness was correlated with age (P = 0.05; r = 0.35), WHR (P = 0.003; r = 0.67), daily insulin dose/kg (r = 0.45, P = 0.005), and eGDR (r = -0.55, P = 0.0004). Multivariate analysis revealed WHR and eGDR to be related to EAT among age, WHR, daily insulin dose/kg, eGDR, FBG, and hemoglobin A1c (r(2) of the model = 0.64). Epicardial adipose tissue thickness is increased in type 1 diabetic patients compared to controls and is related to WHR and eGDR in this group of patients. This measurement may point to the presence of insulin resistance in type 1 diabetic patients.
dc.identifier.doi10.1007/s12020-011-9478-x
dc.identifier.eissn1559-0100
dc.identifier.issn1355-008X
dc.identifier.pubmed21553302
dc.identifier.urihttps://hdl.handle.net/11424/230236
dc.identifier.wosWOS:000296787800014
dc.language.isoeng
dc.publisherSPRINGER
dc.relation.ispartofENDOCRINE
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectEpicardial adipose tissue thickness
dc.subjectType 1 diabetes mellitus
dc.subjectInsulin resistance
dc.subjectEstimated glucose disposal rate
dc.subjectCARDIOVASCULAR RISK-FACTORS
dc.subjectCORONARY-HEART-DISEASE
dc.subjectMETABOLIC SYNDROME
dc.subjectINSULIN-RESISTANCE
dc.subjectPITTSBURGH EPIDEMIOLOGY
dc.subjectFAT
dc.subjectCOMPLICATIONS
dc.subjectSEVERITY
dc.subjectECHOCARDIOGRAPHY
dc.subjectASSOCIATION
dc.titleEpicardial adipose tissue thickness in type 1 diabetic patients
dc.typearticle
dspace.entity.typePublication
local.avesis.idd7bb377a-cd8d-49ff-b495-575b6714feec
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages6
oaire.citation.endPage255
oaire.citation.issue2
oaire.citation.startPage250
oaire.citation.titleENDOCRINE
oaire.citation.volume40
relation.isAuthorOfPublicationa3b8b4a2-fc05-4f42-b6ec-5a452471f501
relation.isAuthorOfPublication.latestForDiscoverya3b8b4a2-fc05-4f42-b6ec-5a452471f501

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