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Investigation of the association between mitochondrial DNA and p53 gene mutations in transitional cell carcinoma of the bladder

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dc.contributor.authorGÜNEY, AHMET İLTER
dc.contributor.authorsAvcilar, Tuba; Kirac, Deniz; Ergec, Deniz; Koc, Gulsah; Ulucan, Korkut; Kaya, Zehra; Kaspar, Elif Cigdem; Turkeri, Levent; Guney, Ahmet Ilter
dc.date.accessioned2022-03-14T08:14:26Z
dc.date.available2022-03-14T08:14:26Z
dc.date.issued2016-10
dc.description.abstractBladder carcinoma is the most common malignancy of the urinary tract. The major aim of the present study is to investigate the association between mitochondrial DNA (mtDNA) and p53 gene mutations in bladder carcinoma. A total of 30 patients with transitional cell carcinoma and 27 controls were recruited for the study. Bladder cancer tissues were obtained by radical cystectomy or transurethral resection. Genomic DNA was extracted from peripheral blood. mtDNA and p53 genes were amplified by polymerase chain reaction and sequenced directly. A total of 37 polymorphisms were identified, among which, 2 mutations were significant in the patient group, and 1 mutation was significant in the control group. Additionally, 5 different moderate positive correlations between mtDNA mutations and 3 different positive correlations between p53 gene and mtDNA mutations were detected. The high incidence of mtDNA and p53 gene mutations in bladder cancer suggests that these genes could be important in carcinogenesis.
dc.identifier.doi10.3892/ol.2016.5000
dc.identifier.eissn1792-1082
dc.identifier.issn1792-1074
dc.identifier.pubmed27698873
dc.identifier.urihttps://hdl.handle.net/11424/241243
dc.identifier.wosWOS:000385579200098
dc.language.isoeng
dc.publisherSPANDIDOS PUBL LTD
dc.relation.ispartofONCOLOGY LETTERS
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectbladder carcinoma
dc.subjectmtDNA
dc.subjectp53
dc.subjectTCC
dc.subjectURINARY-BLADDER
dc.subjectCANCER
dc.titleInvestigation of the association between mitochondrial DNA and p53 gene mutations in transitional cell carcinoma of the bladder
dc.typearticle
dspace.entity.typePublication
local.avesis.id957f0afb-e043-43eb-8a54-569b62b40f13
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages8
local.journal.quartileQ4
oaire.citation.endPage2879
oaire.citation.issue4
oaire.citation.startPage2872
oaire.citation.titleONCOLOGY LETTERS
oaire.citation.volume12
relation.isAuthorOfPublicationd474fc8a-ae88-487e-b63b-7f506191fb94
relation.isAuthorOfPublication.latestForDiscoveryd474fc8a-ae88-487e-b63b-7f506191fb94

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