Publication:
DOES PGE(2) ACT AS A MEDIATOR FOR ENDOTHELIN RELEASE

Simple item page
dc.contributor.authorHAKLAR, GONCAGÜL
dc.contributor.authorsAKTAN, AO; BUYUKGEBIZ, O; YEGEN, C; YALCIN, SH; HAKLAR, G; YALIN, R; ERCAN, S
dc.date.accessioned2022-03-12T16:56:29Z
dc.date.available2022-03-12T16:56:29Z
dc.date.issued1994
dc.description.abstractTo investigate the effect of iloprost (ZK 36374) and thromboxane synthetase inhibitor UK 38485 on endothelin release by the intestinal vascular endothelium after ischemia/reperfusion (IR) injury, five experimental groups were formed. The groups consisted of sham, control, iloprost treated (ILO), UK 38485 treated (TSI), and iloprost + UK 38485 treated (ILO + TSI) groups. The last three groups received the corresponding agents and then the superior mesenteric artery was clamped for 30 min followed by 90 min reperfusion. Endothelin levels in the portal blood and malondialdehyde (MDA), prostaglandin E(2) (PGE(2)) and leukotriene C-4 (LTC(4)) levels in the intestinal tissue were determined. The MDA levels increased significantly in the control group and this increase was reversed in ILO, TSI, and ILO + TSI groups, the two drugs together showing a synergistic effect in preventing lipid peroxidation. The changes in the LTC, levels were not significant among the groups. The increased endothelin levels in the control group were reversed in ILO and TSI groups but these two agents did not have a synergistic effect. Increased PGE, levels were reversed with iloprost but neither UK 38485 nor the combination of the two agents was effective in decreasing PGE, levels. It is concluded that endothelin release after mesenteric IR injury is relatively unrelated to lipid peroxidation and the lipoxygenase pathway. The cyclooxygenase pathway has a direct effect on endothelin release and PGE, may act as a mediator.
dc.identifier.doi10.1016/0952-3278(94)90103-1
dc.identifier.issn0952-3278
dc.identifier.pubmed7511821
dc.identifier.urihttps://hdl.handle.net/11424/226772
dc.identifier.wosWOS:A1994MP27100003
dc.language.isoeng
dc.publisherCHURCHILL LIVINGSTONE
dc.relation.ispartofPROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectISCHEMIA-REPERFUSION INJURY
dc.subjectGUINEA-PIG
dc.subjectPROSTACYCLIN
dc.titleDOES PGE(2) ACT AS A MEDIATOR FOR ENDOTHELIN RELEASE
dc.typearticle
dspace.entity.typePublication
local.avesis.id24bdca3a-ec28-4091-b0dc-eb7f5c63aaee
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages5
oaire.citation.endPage41
oaire.citation.issue1
oaire.citation.startPage37
oaire.citation.titlePROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
oaire.citation.volume50
relation.isAuthorOfPublication27f9fd8a-7791-4b61-a4c5-518c52435a15
relation.isAuthorOfPublication.latestForDiscovery27f9fd8a-7791-4b61-a4c5-518c52435a15

Files

Collections

Research Outputs