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Biocompatible polyvinyl alcohol nanofibers loaded with amoxicillin and salicylic acid to prevent wound infections.

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dc.contributor.authorŞAHİN, ALİ
dc.contributor.authorsAydin A., Ulag S., Sahin A., Aksu B., Gunduz O., Ustundag C. B., Marinas I. C., Georgescu M., Chifiriuc M. C.
dc.date.accessioned2023-08-23T07:07:52Z
dc.date.available2023-08-23T07:07:52Z
dc.date.issued2023-08-21
dc.description.abstractDiabetic wounds are one of the most challenging clinical conditions in diabetes, necessitating the development of new treatments to foster healing and prevent microbial contamination. In this study, polyvinyl alcohol (PVA) was used as a matrix polymer, and amoxicillin (AMX) and salicylic acid (SA) were selected as bioactive compounds with antimicrobial (with AMX) and anti-inflammatory action (with SA) to obtain innovative drug-loaded electrospun nanofiber patches for the management of diabetic wounds. Scanning electron microscopy (SEM) images revealed the uniform and beadless structure of the nanofiber patches. Mechanical tests indicated that AMX minimally increased the tensile strength, while SA significantly reduced it. The patches demonstrated effective antibacterial activity against both grampositive (Staphylococcus aureus) and gram-negative (Escherichia coli) strains. The potential of these patches in the development of novel wound dressings is highlighted by the excellent biocompatibility with fibroblast cells maintained for up to 7 days. Keywords: antibiotic; wound dressing; biocompatibility; antimicrobial activity, drug delivery
dc.identifier.citationAydin A., Ulag S., Sahin A., Aksu B., Gunduz O., Ustundag C. B., Marinas I. C., Georgescu M., Chifiriuc M. C., "Biocompatible polyvinyl alcohol nanofibers loaded with amoxicillin and salicylic acid to prevent wound infections.", Biomedical materials (Bristol, England), 2023
dc.identifier.doi10.1088/1748-605x/acf25c
dc.identifier.issn1748-6041
dc.identifier.urihttps://hdl.handle.net/11424/292791
dc.language.isoeng
dc.relation.ispartofBiomedical materials (Bristol, England)
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectantibiotic
dc.subjectwound dressing
dc.subjectbiocompatibility
dc.subjectantimicrobial activity
dc.subjectdrug delivery
dc.titleBiocompatible polyvinyl alcohol nanofibers loaded with amoxicillin and salicylic acid to prevent wound infections.
dc.typearticle
dspace.entity.typePublication
local.avesis.id1b700a66-16fb-4180-9d63-03bb20bca4f2
local.indexed.atPUBMED
relation.isAuthorOfPublicationf1a7e350-6b40-4248-ac75-bd39aa3e50b0
relation.isAuthorOfPublication.latestForDiscoveryf1a7e350-6b40-4248-ac75-bd39aa3e50b0

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