Publication:
T4 plus T3 Treatment in Children with Hypothyroidism and Inappropriately Elevated Thyroid-Stimulating Hormone despite Euthyroidism on T4 Treatment

Simple item page
dc.contributor.authorBEREKET, ABDULLAH
dc.contributor.authorsAkcay, Teoman; Turan, Serap; Guran, Tulay; Unluguzel, Goksenin; Haklar, Goncagul; Bereket, Abdullah
dc.date.accessioned2022-03-12T17:47:28Z
dc.date.available2022-03-12T17:47:28Z
dc.date.issued2010
dc.description.abstractAims: To evaluate the effect of addition of T3 to L-T4 treatment in children with congenital hypothyroidism (CH) who have inappropriately elevated thyroid-stimulating hormone (TSH) levels despite high normal serum T4 levels on L-T4 treatment. Methods: Ten children (age 7.1 +/- 2 years) with CH whose TSH levels were persistently high despite euthyroidism and can only be normalized with hyperthyroidism were included. L-T4 treatment was switched to T3+L-T4 combination (Bitiron (R) tablet 50 mu g L-T4 + 12.5 mu g triiodothyronine). The patients received 50% of their usual L-T4 dose as L-T4 and the remaining half as T3 in a 4: 1 ratio. The dose of T3+L-T4 was titrated to achieve normal TSH levels. Thyroid hormones and biochemical markers were followed for 1 year. Results: Euthyrotropinemia was achieved at the 7th month (mean) of combination (T3+L-T4) treatment. Serum T4 and fT4 were lower and T3 was higher during combination compared to L-T4 treatment. LDL-cholesterol decreased and ALP increased in the euthyrotropinemic state. Vital signs were similar at hyperthyrotropinemia and euthyrotropinemia. Conclusion: T3+L-T4 treatment provides euthyrotropinemia without causing hyperthyroidism in children with CH and inappropriate hyperthyrotropinemia. Our data strongly suggest that decreased negative feedback due to lower T3 levels at the pituitary level is the main reason for persistent hyperthyrotropinemia. Copyright (C) 2010 S. Karger AG, Basel
dc.identifier.doi10.1159/000277627
dc.identifier.issn1663-2818
dc.identifier.pubmed20190547
dc.identifier.urihttps://hdl.handle.net/11424/229764
dc.identifier.wosWOS:000276919500004
dc.language.isoeng
dc.publisherKARGER
dc.relation.ispartofHORMONE RESEARCH IN PAEDIATRICS
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCongenital hypothyroidism
dc.subjectL-T4
dc.subjectT4+T3 treatment
dc.subjectCombination treatment
dc.subjectInappropriate hyperthyrotropinemia
dc.subjectCONGENITAL HYPOTHYROIDISM
dc.subjectREPLACEMENT THERAPY
dc.subjectL-THYROXINE
dc.subjectTRIIODOTHYRONINE
dc.subjectTHYROTROPIN
dc.subjectSERUM
dc.subjectLEVOTHYROXINE
dc.subjectLIOTHYRONINE
dc.subjectRAT
dc.subject3,5,3'-TRIIODOTHYRONINE
dc.titleT4 plus T3 Treatment in Children with Hypothyroidism and Inappropriately Elevated Thyroid-Stimulating Hormone despite Euthyroidism on T4 Treatment
dc.typearticle
dspace.entity.typePublication
local.avesis.ide6719e26-39bc-49a4-8556-17c50eb85088
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages7
oaire.citation.endPage114
oaire.citation.issue2
oaire.citation.startPage108
oaire.citation.titleHORMONE RESEARCH IN PAEDIATRICS
oaire.citation.volume73
relation.isAuthorOfPublication669e9474-4e39-453f-a4bc-4ede9cb5abac
relation.isAuthorOfPublication.latestForDiscovery669e9474-4e39-453f-a4bc-4ede9cb5abac

Files

Collections

Research Outputs