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The role of procalcitonin as a biomarker for acute pulmonary exacerbation in subjects with cystic fibrosis and non-cystic fibrosis bronchiectasis

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dc.contributor.authorKOCAKAYA, DERYA
dc.contributor.authorARIKAN, HÜSEYİN
dc.contributor.authorERYÜKSEL, SEMİHA EMEL
dc.contributor.authorCEYHAN, BERRİN
dc.contributor.authorsMammadov F., Olgun Yildizel S., Kocakaya D., ARIKAN H., Cinar C., Eryuksel E., CEYHAN B.
dc.date.accessioned2023-06-14T10:25:17Z
dc.date.available2023-06-14T10:25:17Z
dc.date.issued2022-01-01
dc.description.abstractObjective: Patients with cystic fibrosis (CF) and non-CF bronchiectasis are prone to exacerbations of pulmonary infections. C-reactive protein (CRP) and procalcitonin (PCT) are inflammatory markers. The aim of this study is to evaluate the role of CRP and PCT on exacerbations of CF and non-CF bronchiectasis. Patients and Methods: The medical records of 18 CF (52 hospitalizations) and 20 non-CF bronchiectasis patients (51 hospitalizations) were reviewed retrospectively. CRP, PCT levels and, white blood cell (WBC) counts on admission and follow-up were evaluated. Results: C-reactive protein levels correlated with PCT levels on admission in all patients. Baseline PCT levels were markedly higher (>0.5µg/L) in 12% of CF and 10% of non-CF bronchiectasis patients, however, baseline CRP values were markedly higher (>5mg/L) in 96% of CF and non-CF bronchiectasis patients (p=0.760 and p=0.100, respectively). Baseline CRP and PCT levels were positively correlated with hospitalization length (r=0.501, p=0.001 and r=0.289, p=0.04, respectively) in CF patients, but not in non-CF bronchiectasis. Conclusion: Our study shows the potential utility of these biomarkers to determine the severity of the exacerbation particularly predicting hospitalization length in CF patients. Both biomarkers could be able to guide antibiotic treatment of infective exacerbations in CF and non-CF bronchiectasis patients.
dc.identifier.citationMammadov F., Olgun Yildizel S., Kocakaya D., ARIKAN H., Cinar C., Eryuksel E., CEYHAN B., "The role of procalcitonin as a biomarker for acute pulmonary exacerbation in subjects with cystic fibrosis and non-cystic fibrosis bronchiectasis", MARMARA MEDICAL JOURNAL, cilt.35, sa.2, ss.164-171, 2022
dc.identifier.doi10.5472/marumj.1114952
dc.identifier.endpage171
dc.identifier.issn1309-9469
dc.identifier.issue2
dc.identifier.startpage164
dc.identifier.urihttps://avesis.marmara.edu.tr/api/publication/efd0a314-ab7c-4c0b-ad03-770ffa45c93a/file
dc.identifier.urihttps://hdl.handle.net/11424/290259
dc.identifier.volume35
dc.language.isoeng
dc.relation.ispartofMARMARA MEDICAL JOURNAL
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectMedicine
dc.subjectHealth Sciences
dc.subjectFundamental Medical Sciences
dc.subjectTIP, GENEL & DAHİLİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectMEDICINE, GENERAL & INTERNAL
dc.subjectCLINICAL MEDICINE
dc.subjectClinical Medicine (MED)
dc.subjectGenel Sağlık Meslekleri
dc.subjectPatofizyoloji
dc.subjectTemel Bilgi ve Beceriler
dc.subjectDeğerlendirme ve Teşhis
dc.subjectDahiliye
dc.subjectAile Sağlığı
dc.subjectTıp (çeşitli)
dc.subjectGenel Tıp
dc.subjectGeneral Health Professions
dc.subjectPathophysiology
dc.subjectFundamentals and Skills
dc.subjectAssessment and Diagnosis
dc.subjectInternal Medicine
dc.subjectFamily Practice
dc.subjectMedicine (miscellaneous)
dc.subjectGeneral Medicine
dc.subjectCystic fibrosis
dc.subjectBronchiectasis
dc.subjectExacerbation
dc.subjectInfection
dc.subjectProcalcitonin
dc.subjectC-reactive protein
dc.subjectC-REACTIVE PROTEIN
dc.subjectSERUM PROCALCITONIN
dc.subjectADULT PATIENTS
dc.subjectPATHOPHYSIOLOGY
dc.subjectINFECTIONS
dc.subjectGUIDANCE
dc.subjectTHERAPY
dc.subjectMARKERS
dc.subjectCystic fibrosis
dc.subjectBronchiectasis
dc.subjectExacerbation
dc.subjectInfection
dc.subjectProcalcitonin
dc.subjectC-reactive protein
dc.titleThe role of procalcitonin as a biomarker for acute pulmonary exacerbation in subjects with cystic fibrosis and non-cystic fibrosis bronchiectasis
dc.typearticle
dspace.entity.typePublication
local.avesis.idefd0a314-ab7c-4c0b-ad03-770ffa45c93a
local.indexed.atWOS
local.indexed.atSCOPUS
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relation.isAuthorOfPublication9520db73-1133-4294-8202-da397a93980b
relation.isAuthorOfPublication14f2d015-b03a-45e7-bb38-e82572308bca
relation.isAuthorOfPublication.latestForDiscovery2771cdd6-7c3b-45a8-89fe-a429a2950516

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