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Exogenous L-Arginine and HDL Can Alter LDL and ox-LDL-Mediated Platelet Activation: Using Platelet P-Selectin Receptor Numbers

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dc.contributor.authorŞENER, AZİZE
dc.contributor.authorsSener, Azize; Enc, Elif; Ozsavci, Derya; Vanizor-Kural, Birgul; Yanikkaya-Demirel, Gulderen; Oba, Rabia; Uras, Fikriye; Demir, Muzaffer
dc.date.accessioned2022-03-12T18:04:57Z
dc.date.available2022-03-12T18:04:57Z
dc.date.issued2011
dc.description.abstractThe aim of this study is to investigate the effects of exogenous L-arginine and HDL on LDL and oxidized LDL (ox-LDL)-mediated platelet activation. Adenosine diphosphate (ADP)-activated platelets have been incubated with lipoproteins with or without L-arginine. P-selectin receptor numbers per platelet have been measured by flow cytometry. After incubation with only L-arginine (without lipoproteins), platelet nitric oxide (NO) levels and P-selectin receptor numbers significantly increased compared to the controls (P < .05). After incubation with LDL or ox-LDL, receptor numbers of P-selectin significantly increased (P < .001). However, P-selectin receptor numbers in platelets treated with L-arginine + LDL or L-arginine + ox-LDL decreased compared to the levels in platelets treated with only LDL or ox-LDL (P < .01, P < .001, respectively). Addition of HDL to L-arginine + ox-LDL caused significant reduction in P-selectin receptor numbers as in the control values (P < .001). We have concluded that L-arginine causes enhanced platelet NO levels and blocks the effects of LDL or ox-LDL on platelet P-selectin receptor numbers and HDL also strengthens this effect of L-arginine.
dc.identifier.doi10.1177/1076029610385223
dc.identifier.eissn1938-2723
dc.identifier.issn1076-0296
dc.identifier.pubmed21078607
dc.identifier.urihttps://hdl.handle.net/11424/230533
dc.identifier.wosWOS:000300376400016
dc.language.isoeng
dc.publisherSAGE PUBLICATIONS INC
dc.relation.ispartofCLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectnitric oxide
dc.subjectlow-density lipoprotein
dc.subjecthigh density lipoprotein
dc.subjectoxidized low-density lipoprotein
dc.subjectplatelet
dc.subjectL-arginine
dc.subjectP-selectin
dc.subjectNITRIC-OXIDE SYNTHASE
dc.subjectLOW-DENSITY-LIPOPROTEIN
dc.subjectOXIDIZED-LDL
dc.subjectEXPRESSION
dc.subjectRISK
dc.subjectATHEROSCLEROSIS
dc.subjectAGGREGATION
dc.subjectPARAOXONASE
dc.subjectLEUKOCYTE
dc.subjectTRANSPORT
dc.titleExogenous L-Arginine and HDL Can Alter LDL and ox-LDL-Mediated Platelet Activation: Using Platelet P-Selectin Receptor Numbers
dc.typearticle
dspace.entity.typePublication
local.avesis.idda1c1640-4e63-4a5c-9b70-0f30a2edfb32
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages8
oaire.citation.endPageE86
oaire.citation.issue6
oaire.citation.startPageE79
oaire.citation.titleCLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
oaire.citation.volume17
relation.isAuthorOfPublicationfd65174e-4126-41c3-913d-e8bcdce20632
relation.isAuthorOfPublication.latestForDiscoveryfd65174e-4126-41c3-913d-e8bcdce20632

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