Publication:
Utilisation of Rhododendron luteum Sweet bioactive compounds as valuable source of enzymes inhibitors, antioxidant, and anticancer agents

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dc.contributor.authorŞENKARDEŞ, İSMAİL
dc.contributor.authorsMahomoodally, Mohamad Fawzi; Sieniawska, Elwira; Sinan, Kouadio Ibrahime; Picot-Allain, Marie Carene Nancy; Yerlikaya, Serife; Baloglu, Mehmet Cengiz; Altunoglu, Yasemin Celik; Senkardes, Ismail; Rengasamy, Kannan R. R.; Zengin, Gokhan
dc.date.accessioned2022-03-12T16:24:46Z
dc.date.available2022-03-12T16:24:46Z
dc.date.issued2020
dc.description.abstractEthnobotanical evidences report the use of Rhododendron luteum Sweet (Ericaceae) in traditional medicinal systems. However, R. luteum has been associated to the occurrence of 'mad honey' poisoning. In the present study, the ethyl acetate, methanol, and water extracts of R. luteum were investigated for their in vitro antioxidant, enzyme inhibition, and cytotoxic properties. The cytotoxicity of R. luteum extracts on A549 lung cancer cell line was evaluated using MTT cell viability assay. Besides, HPLC-ESI-MSn approach was employed to elucidate the secondary metabolite profiles of R. luteum in order to establish any structure-activity relationship. Methanol and water extracts of R. luteum possessed highest radical scavenging and reducing properties while the ethyl acetate extract showed highest metal chelating properties. In terms of enzyme inhibition, the methanol and ethyl acetate extracts of R. luteum, possessing epigallocatechin, were active inhibitors of cholinesterase enzymes, a-glucosidase, and tyrosinase. Water extract caused growth inhibition of A549 cells with 207.2 mu g/ml IC50 value. Though R. luteum has received little scientific attention due to the occurrence of grayanotoxins in the plant, however, data presented in this work shows promising biological activity of R. luteum and highlighted its role as a potential source of antioxidant and key enzyme inhibitors.
dc.identifier.doi10.1016/j.fct.2019.111052
dc.identifier.eissn1873-6351
dc.identifier.issn0278-6915
dc.identifier.pubmed31837349
dc.identifier.urihttps://hdl.handle.net/11424/226446
dc.identifier.wosWOS:000509791400046
dc.language.isoeng
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.relation.ispartofFOOD AND CHEMICAL TOXICOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectYellow azalea
dc.subjectHoneysuckle azalea
dc.subjectEnzyme inhibitory
dc.subjectAnticancer
dc.subjectPCA analysis
dc.subjectIN-VITRO
dc.subjectFERULIC ACID
dc.subjectASPHODELINE-ANATOLICA
dc.subjectEXTRACTION TECHNIQUES
dc.subjectALZHEIMERS-DISEASE
dc.subjectCAFFEIC ACID
dc.subjectBUTYRYLCHOLINESTERASE
dc.subjectACETYLCHOLINESTERASE
dc.subjectFLAVONOL
dc.subjectMSN
dc.titleUtilisation of Rhododendron luteum Sweet bioactive compounds as valuable source of enzymes inhibitors, antioxidant, and anticancer agents
dc.typeconferenceObject
dspace.entity.typePublication
local.avesis.id4cee55c7-e29b-48cf-83f7-9e01b6ffe62b
local.conference.date2019
local.conference.locationChillan, CHILE
local.conference.title10th International Symposium on Natural Products Chemistry and Applications (ISNPCA)
local.import.packageSS15
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.articlenumber111052
local.journal.numberofpages9
local.journal.quartileQ1
oaire.citation.titleFOOD AND CHEMICAL TOXICOLOGY
oaire.citation.volume135
relation.isAuthorOfPublication3e59035c-d7b1-4887-b78c-2a9bc207de05
relation.isAuthorOfPublication.latestForDiscovery3e59035c-d7b1-4887-b78c-2a9bc207de05

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