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Effects of captopril and losartan on lipid peroxidation, protein oxidation and nitric oxide release in diabetic rat kidney

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dc.contributor.authorYAVUZ, DİLEK
dc.contributor.authorsYavuz, Dilek; Küçükkaya, Belgin; Haklar, Goncagül; Ersöz, Onder; Akoğlu, Emel; Akalin, Sema
dc.date.accessioned2022-03-15T11:26:28Z
dc.date.available2022-03-15T11:26:28Z
dc.date.issued2003
dc.description.abstractIncreased oxidative stress has an important role in the pathogenesis of diabetic nephropathy. The aim of this study was to evaluate the effects of renin-anigiotensin system blockage, either by angiotensin-converting enzyme inhibition or angiotensin receptor blockage, on oxidative stress and nitric oxide release in diabetic rat kidneys. After induction of diabetes, six rats were given captopril, six rats were given losartan, and six rats served as diabetic controls. Six healthy rats were also included. At the end of an 8-week period nitric oxide release, lipid peroxidation and protein oxidation were measured in kidney cortices, and urinary albumin excretion (UAE) was determined in 24-h urine samples. Losartan- and captopril-treated diabetic rats had lower levels of UAE than diabetic controls. Diabetic rats had higher levels of lipid peroxidation and protein oxidation compared to healthy rats. NO release was significantly lower in diabetic groups than healthy controls. UAE levels showed a positive correlation with lipid peroxidation and a negative correlation with NO release. Inhibition of lipid peroxidation could be one of the protective mechanisms of renin-angiotensin axis inhibition in diabetic kidney tissues.
dc.identifier.doi10.1016/s0952-3278(03)00088-7
dc.identifier.issn0952-3278
dc.identifier.pubmedPMID: 12907131
dc.identifier.urihttps://hdl.handle.net/11424/250383
dc.language.isoeng
dc.relation.ispartofProstaglandins, Leukotrienes, and Essential Fatty Acids
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectFemale
dc.subjectAnimals
dc.subjectRats
dc.subjectAntihypertensive Agents
dc.subjectProteins
dc.subjectRats, Wistar
dc.subjectLipid Peroxidation
dc.subjectOxidative Stress
dc.subjectNitric Oxide
dc.subjectKidney
dc.subjectOxidation-Reduction
dc.subjectDiabetic Nephropathies
dc.subjectDiabetes Mellitus, Experimental
dc.subjectCaptopril
dc.subjectAngiotensin-Converting Enzyme Inhibitors
dc.subjectAngiotensin Receptor Antagonists
dc.subjectLosartan
dc.titleEffects of captopril and losartan on lipid peroxidation, protein oxidation and nitric oxide release in diabetic rat kidney
dc.typearticle
dspace.entity.typePublication
local.avesis.ide6fefbfb-fbb3-48d6-b6ed-5f905ab0a703
local.import.packageSS23
local.import.sourcePubMed
local.indexed.atPUBMED
oaire.citation.endPage227
oaire.citation.startPage223
oaire.citation.titleProstaglandins, Leukotrienes, and Essential Fatty Acids
oaire.citation.volume4
relation.isAuthorOfPublication26174ec5-7dca-4038-a7fe-9a43f236fd15
relation.isAuthorOfPublication.latestForDiscovery26174ec5-7dca-4038-a7fe-9a43f236fd15

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