Publication:
Contemporary Trends in Adjuvant and Neoadjuvant Treatment for Renal Cell Carcinoma

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dc.contributor.authorÇAM, HAYDAR KAMİL
dc.contributor.authorsCam, Kamil
dc.date.accessioned2022-03-10T11:38:40Z
dc.date.available2022-03-10T11:38:40Z
dc.date.issued2018-09-01
dc.description.abstractRenal cell carcinoma is an increasingly significant cancer in which surgical resection is still the sole curative approach. There is a risk of recurrence in one-third of patients after surgery. Successful experiences with some solid organ cancers and effective treatment response to targeted agents in metastatic cases have suggested a similar adjuvant approach for renal cell carcinoma. Consequently, placebo-controlled adjuvant trials have been reported and the Food and Drug Administration approved sunutinib as an adjuvant treatment after nephrectomy in high-risk patients, with the risk of treatment-related side effects. Several clinical series have indicated that neoadjuvant application can provide significant downsizing of the cancer mass in complex cases and enable radical surgery. Similarly, neoadjuvant therapy could enable nephron-sparing surgery for certain patients. Both adjuvant and neoadjuvant approaches for renal cell carcinoma require further trials with larger patient numbers. This review presents contemporary experience on adjuvant and neoadjuvant treatment for renal cell carcinoma.
dc.identifier.doi10.4274/uob.1030
dc.identifier.issn2147-2270
dc.identifier.urihttps://hdl.handle.net/11424/219774
dc.identifier.wosWOS:000444494100005
dc.language.isoeng
dc.publisherGALENOS YAYINCILIK
dc.relation.ispartofUROONKOLOJI BULTENI-BULLETIN OF UROONCOLOGY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectRenal cell carcinoma
dc.subjectadjuvant
dc.subjectneoadjuvant
dc.subjecttargeted therapy
dc.subjectTARGETED MOLECULAR THERAPIES
dc.subjectRADICAL NEPHRECTOMY
dc.subjectPHASE-III
dc.subjectCLINICAL-TRIALS
dc.subjectSTAGE-II
dc.subjectRISK
dc.subjectSUNITINIB
dc.subjectCANCER
dc.subjectSURGERY
dc.subjectSORAFENIB
dc.titleContemporary Trends in Adjuvant and Neoadjuvant Treatment for Renal Cell Carcinoma
dc.typereview
dspace.entity.typePublication
local.avesis.idd8aa94fc-7149-491f-a6c6-b5a9996852bf
local.import.packageSS4
local.indexed.atWOS
local.indexed.atTRDIZIN
local.journal.numberofpages7
oaire.citation.endPage104
oaire.citation.issue3
oaire.citation.startPage98
oaire.citation.titleUROONKOLOJI BULTENI-BULLETIN OF UROONCOLOGY
oaire.citation.volume17
relation.isAuthorOfPublication0c106ff1-322f-462b-b801-f32c03858a19
relation.isAuthorOfPublication.latestForDiscovery0c106ff1-322f-462b-b801-f32c03858a19

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