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Correlation of Histopathological Findings in Laryngeal Squamous Cell Carcinoma with Inflammatory Biomarkers

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dc.contributor.authorOYSU, ÇAĞATAY
dc.contributor.authorsDeveci, Ildem; Surmeli, Mehmet; Onder, Serap; Karabulut, Burak; Deveci, Hande Senem; Oysu, Cagatay
dc.date.accessioned2022-03-12T22:38:33Z
dc.date.available2022-03-12T22:38:33Z
dc.date.issued2019
dc.description.abstractObjective: The goal of this research was to investigate how biomarkers, i.e. SII (an index calculated from blood counts of various leucocytes), NLR and MLR correlate with features used in the staging of laryngeal squamous cell carcinoma (LSCC), i.e. perineural infiltration, lymphatic involvement and histological grade. Methods: A retrospective review of clinical records from 146 cases (143 men and 3 women) of LSCC occurring between January 2008 and January 2018 was undertaken. The sample included every stage of LSCC and all biomarker results were found from the full blood count (FBC) results obtained prior to surgery and documented for each case. SII is a newly introduced index of inflammation calculated according to the formula: SII = NxP/L, where N represents neutrophil, P platelet and L lymphocyte counts. Histopathological parameters (presence of perineural or lymphatic involvement, grade of tumour) were evaluated alongside results for NLR, MLR and SII. Results: All three biomarkers were different at the level of statistical significance between individuals with LSCC and the controls. For NLR, p=0.003; for MLR, p=0.008; for SII, p<0.001. Both NLR and SII were different at a statistically significant level when compared at early and advanced stages of LSCC (p values were 0.011 and <0.001, respectively. MLR did not differ at the level of statistical significance (p=0.944). (See Table 3). Conclusion: SII is straightforward to calculate, economical and reproducible from FBC results. It can provide important clues to the likelihood of perineural or lymphatic involvement in cases of LSCC.
dc.identifier.doi10.32448/entupdates.541148
dc.identifier.eissn2149-6498
dc.identifier.issn2149-7109
dc.identifier.urihttps://hdl.handle.net/11424/235665
dc.identifier.wosWOS:000493732700009
dc.language.isoeng
dc.publisherDEOMED PUBL, ISTANBUL
dc.relation.ispartofENT UPDATES
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectLaryngeal squamous cell carcinoma
dc.subjectinflammatory biomarkers
dc.subjectsystemic immune-inflammation index
dc.subjectTO-LYMPHOCYTE RATIO
dc.subjectCURATIVE RESECTION
dc.subjectPROGNOSTIC-FACTOR
dc.subjectCANCER
dc.subjectNEUTROPHIL
dc.subjectSURVIVAL
dc.subjectCOUNTS
dc.subjectTUMORS
dc.subjectINDEX
dc.titleCorrelation of Histopathological Findings in Laryngeal Squamous Cell Carcinoma with Inflammatory Biomarkers
dc.typearticle
dspace.entity.typePublication
local.avesis.id9926533d-679c-49ac-808e-dce90ee3fa0d
local.import.packageSS17
local.indexed.atWOS
local.indexed.atTRDIZIN
local.journal.numberofpages9
oaire.citation.endPage52
oaire.citation.issue1
oaire.citation.startPage44
oaire.citation.titleENT UPDATES
oaire.citation.volume9
relation.isAuthorOfPublicationec6e486e-15b1-4c25-910f-5f85ab2fbaf4
relation.isAuthorOfPublication.latestForDiscoveryec6e486e-15b1-4c25-910f-5f85ab2fbaf4

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