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Protective effect of ferulic acid on cisplatin induced nephrotoxicity in rats

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dc.contributor.authorOKUYAN, BETÜL
dc.contributor.authorsBami, Erliasa; Ozakpinar, Ozlem Bingol; Ozdemir-Kumral, Zarife Nigar; Koroglu, Kutay; Ercan, Feriha; Cirakli, Zeynep; Sekerler, Turgut; Izzettin, Fikret Vehbi; Sancar, Mesut; Okuyan, Betul
dc.date.accessioned2022-03-12T20:32:46Z
dc.date.available2022-03-12T20:32:46Z
dc.date.issued2017
dc.description.abstractThis study aims to determine the potential protective effects of ferulic acid against cisplatin-induced nephrotoxicity and to compare its effect with curcumin, a well-known protective agent against cisplatin- induced toxicity in rats. Administration of cisplatin resulted in high BUN (Blood Urea Nitrogen), creatinine, MDA (Malondialdehyde), MPO (Myeloperoxidase), TOS (Total Oxidative Status), PtNT (Protein Nitrotyrosine) levels (p < 0.05). Histological observations showed abnormal morphology of kidney; in addition with appearance of TUNEL positive cells indicating apoptosis in cisplatin administered group. HO-1 (Heme Oxygenase-1) levels measured by RT-PCR (Real Time Polymerase Chain Reaction), and TAS (Total Antioxidative Status) revealed antioxidant depletion due to cisplatin toxicity in animals (p < 0.05). All parameters showed improvement in groups treated with ferulic acid (p < 0.05). Ferulic acid treatment was found significant in preventing oxidative stress, increasing antioxidative status and regaining histological parameters to normal, indicating nephroprotective and antioxidant effects of this phenolic compound.
dc.identifier.doi10.1016/j.etap.2017.06.026
dc.identifier.eissn1872-7077
dc.identifier.issn1382-6689
dc.identifier.pubmed28704751
dc.identifier.urihttps://hdl.handle.net/11424/234430
dc.identifier.wosWOS:000409288300015
dc.language.isoeng
dc.publisherELSEVIER
dc.relation.ispartofENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectKidney
dc.subjectCisplatin
dc.subjectFerulic acid
dc.subjectCurctunin
dc.subjectINHIBITING RENAL INFLAMMATION
dc.subjectOXIDATIVE STRESS
dc.subjectCURCUMIN
dc.subjectKIDNEY
dc.subjectINJURY
dc.subjectMECHANISMS
dc.subjectAPOPTOSIS
dc.subjectDAMAGE
dc.subjectBIOMARKER
dc.titleProtective effect of ferulic acid on cisplatin induced nephrotoxicity in rats
dc.typearticle
dspace.entity.typePublication
local.avesis.id3c8e9fd4-ee77-4685-8815-3ba25ca34545
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages7
local.journal.quartileQ2
oaire.citation.endPage111
oaire.citation.startPage105
oaire.citation.titleENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
oaire.citation.volume54
relation.isAuthorOfPublicationf6e7969a-ea61-403f-8772-1a8478556223
relation.isAuthorOfPublication.latestForDiscoveryf6e7969a-ea61-403f-8772-1a8478556223

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