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Long-term BTX-A effects on bi-articular muscle: Higher passive force, limited length range of active force production and unchanged intermuscular interactions

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dc.contributor.authorAKDENİZ DOĞAN, ZEYNEP DENİZ
dc.contributor.authorsYilmaz, Evrim O.; Kaya, Cemre S.; Akdeniz-Dogan, Zeynep D.; Yucesoy, Can A.
dc.date.accessioned2022-03-12T22:56:05Z
dc.date.available2022-03-12T22:56:05Z
dc.date.issued2021
dc.description.abstractBotulinum toxin type-A (BTX-A) is commonly used for spasticity management aiming at reducing joint stiffness and increasing joint range of motion in CP patients. However, previous animal studies showed acutely increased passive forces and a narrower length range of active force exertion (lrange) for muscles exposed. BTX-A can spread affecting mechanics of several muscles in a compartment, but it was shown acutely to diminish epimuscular myofascial force transmission (EMFT). Yet, our understanding of these effects in the long-term is limited and they need to be tested in a bi-articular muscle. The goal was to test the following hypotheses in a long-term rat model: exposure to BTX-A (i) has no effects on lrange and passive forces of bi-articular extensor digitorum longus (EDL) muscle and (ii) diminishes EMFT. Male Wistar rats were divided into two groups: BTX-A and control (0.1 units of BTX-A or only saline was injected into the tibialis anterior). Isometric proximal and distal EDL forces were measured simultaneously, one-month post-injection. Proximally and distally lengthening the muscle showed that BTX-A causes a significantly narrower lrange (by 14.7% distally and 32.2% proximally) and significantly increased passive muscle forces (over 2-fold both distally and proximally). Altering muscle position at constant length showed that BTX-A does not change EMFT. The findings reject both hypotheses showing that long-term exposure to BTX-A compromises bi-articular muscle's contribution to motion for both joints and the muscle's mechanical interaction with the surroundings remains unaffected. These effects which may compromise long-term spasticity management should be studied in CP patients.
dc.identifier.doi10.1016/j.jbiomech.2021.110627
dc.identifier.eissn1873-2380
dc.identifier.issn0021-9290
dc.identifier.pubmed34293603
dc.identifier.urihttps://hdl.handle.net/11424/236887
dc.identifier.wosWOS:000701936800012
dc.language.isoeng
dc.publisherELSEVIER SCI LTD
dc.relation.ispartofJOURNAL OF BIOMECHANICS
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBotulinum toxin type A long-term effects
dc.subjectBi-articular muscle
dc.subjectMuscle passive force
dc.subjectMuscle active force
dc.subjectIntermuscular mechanical interactions
dc.subjectEpimuscular myofascial force transmission
dc.subjectTOXIN TYPE-A
dc.subjectEXTRAMUSCULAR MYOFASCIAL FORCE
dc.subjectBOTULINUM-TOXIN
dc.subjectSPASTIC EQUINUS
dc.subjectCEREBRAL-PALSY
dc.subjectCHILDREN
dc.subjectTRANSMISSION
dc.subjectRAT
dc.subjectCOMPARTMENT
dc.subjectNEUROTOXIN
dc.titleLong-term BTX-A effects on bi-articular muscle: Higher passive force, limited length range of active force production and unchanged intermuscular interactions
dc.typearticle
dspace.entity.typePublication
local.avesis.idbb434f82-cb29-4e29-a6de-a9bf019323ec
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.articlenumber110627
local.journal.numberofpages7
oaire.citation.titleJOURNAL OF BIOMECHANICS
oaire.citation.volume126
relation.isAuthorOfPublication93556b36-aeb6-41da-8b2a-3383d9d6f170
relation.isAuthorOfPublication.latestForDiscovery93556b36-aeb6-41da-8b2a-3383d9d6f170

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