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Thalidomide has both anti-inflammatory and regulatory effects in Behcet's disease

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dc.contributor.authorDİRESKENELİ, RAFİ HANER
dc.contributor.authorsDireskeneli, H.; Ergun, T.; Yavuz, S.; Hamuryudan, V.; Eksioglu-Demiralp, E.
dc.date.accessioned2022-03-12T17:35:21Z
dc.date.available2022-03-12T17:35:21Z
dc.date.issued2008
dc.description.abstractThalidomide is shown to be an effective treatment for mucocutaneous symptoms of Behcet's disease (BD). In this study, the effects of thalidomide on peripheral blood mononuclear cells were investigated ex vivo. In an open prospective study, ten patients were given 200 mg/day thalidomide for 12 weeks and cluster of differentiation 4 (CD4), CD8, CD11a, CD11b, CD16, CD18, CD28, CD44, CD45RO, CD45RA, CD56, CD120a and gamma delta+ T cells were analysed with flow cytometry at 0, 3, 7, 30 and 90 days. Two patients were excluded from the analysis for attacks of uveitis within the first 2 weeks. At day 7, tumour necrosis factor-alpha (TNF-alpha) receptor+ (CD120a; 12% vs 5%), CD8/CD11b+ (12% vs 6%) and CD16/CD56+ (16% vs 9%) cells decreased in BD patients compared to day 0. On the other hand, CD4+CD45RO+ T cells (24% vs 34%) at day 30 and gamma delta+ T cells (11% vs 21%) at day 90 increased after treatment. These results suggest that thalidomide tends to decrease TNF-alpha receptor levels, CD8/CD11b+ T cells and natural killer cells in early treatment and increases CD4+CD45RO+ memory T and gamma delta+ T cells later in BD.
dc.identifier.doi10.1007/s10067-007-0786-8
dc.identifier.issn0770-3198
dc.identifier.pubmed18034203
dc.identifier.urihttps://hdl.handle.net/11424/229151
dc.identifier.wosWOS:000252974700016
dc.language.isoeng
dc.publisherSPRINGER
dc.relation.ispartofCLINICAL RHEUMATOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBehcet's disease
dc.subjectT cells
dc.subjectthalidomide
dc.subjectT-CELLS
dc.subjectACTIVATION
dc.subjectALPHA
dc.subjectTNF
dc.titleThalidomide has both anti-inflammatory and regulatory effects in Behcet's disease
dc.typearticle
dspace.entity.typePublication
local.avesis.id9b7264a7-7d82-46c6-abb2-31423486bac6
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages3
oaire.citation.endPage375
oaire.citation.issue3
oaire.citation.startPage373
oaire.citation.titleCLINICAL RHEUMATOLOGY
oaire.citation.volume27
relation.isAuthorOfPublication07a34d26-21f3-475d-bd36-152d6c659370
relation.isAuthorOfPublication.latestForDiscovery07a34d26-21f3-475d-bd36-152d6c659370

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