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Comparison of Doppler ultrasound and transient elastography in the diagnosis of significant fibrosis in patients with nonalcoholic steatohepatitis

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dc.contributor.authorÇELİKEL, ÇİĞDEM
dc.contributor.authorsErgelen, Rabia; Yilmaz, Yusuf; Asedov, Ruslan; Celikel, Cigdem; Akin, Hakan; Bugdayci, Onur; Altun, Ersan; Tuney, Davut
dc.date.accessioned2022-03-12T20:29:06Z
dc.date.available2022-03-12T20:29:06Z
dc.date.issued2016
dc.description.abstractBackground: Liver fibrosis is an important prognostic determinant in patients with nonalcoholic steatohepatitis (NASH). Hepatic artery resistivity index (HARI) is a doppler ultrasonography (US) parameter that is used to follow up microcirculatory resistance in fatty liver. We aimed to asses whether it is possible to demonstrate significant fibrosis by means of doppler US in comparison with transient elastography (TE) and liver biopsy in NASH patients. Patients and methods: A total of 63 (mean age 47.1 +/- 8.4 years, 39 male, 24 female) biopsy-proven NASH patients were enrolled in this prospective study. The study population was classified into two groups: significant and no-significant fibrosis patients. Doppler US and TE were performed in two groups. Results: HARI and TE values were significantly higher in significant fibrosis group (0.81 +/- 0.05 vs. 0.63 +/- 0.14, p < 0.0005; 15.9 +/- 4.8 vs. 6.2 +/- 2.6 kilopascals, p < 0.0005; respectively). Based on the ROC curve, the optimal cut-off value of HARI for a significant fibrosis was >0.75, which yielded a sensitivity of 78% and a specificity of 75%, with the area under the curve at 0.90. The optimal cut-off value of TE for a significant fibrosis was >9.8 kilopascals, which yielded a sensitivity of 90% and a specificity of 91%, with the area under the curve at 0.95. HARI values were moderately correlated with TE values (r = 0.53, p < 0.001). Conclusion: Doppler US has moderate % sensitivity and % specificity, which is lower compared with TE for the diagnosis significant fibrosis. However, it may be used as an alternative method for the assessment of fibrosis in patients with NASH who are not good candidates for TE evaluation.
dc.identifier.doi10.1007/s00261-016-0699-6
dc.identifier.eissn2366-0058
dc.identifier.issn2366-004X
dc.identifier.pubmed26960729
dc.identifier.urihttps://hdl.handle.net/11424/234025
dc.identifier.wosWOS:000381113400009
dc.language.isoeng
dc.publisherSPRINGER
dc.relation.ispartofABDOMINAL RADIOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectFatty liver
dc.subjectDoppler
dc.subjectFibroscan
dc.subjectNon-alcoholic
dc.subjectFATTY LIVER-DISEASE
dc.subjectCHRONIC HEPATITIS-B
dc.subjectSTIFFNESS MEASUREMENT
dc.subjectCLINICAL-APPLICATION
dc.subjectVIRAL-HEPATITIS
dc.subjectBIOPSY
dc.subjectFIBROTEST
dc.subjectCIRRHOSIS
dc.subjectARTERY
dc.subjectINDEX
dc.titleComparison of Doppler ultrasound and transient elastography in the diagnosis of significant fibrosis in patients with nonalcoholic steatohepatitis
dc.typearticle
dspace.entity.typePublication
local.avesis.id487e9eb1-4717-49a9-863c-04b0f5e5fa45
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages6
local.journal.quartileQ4
oaire.citation.endPage1510
oaire.citation.issue8
oaire.citation.startPage1505
oaire.citation.titleABDOMINAL RADIOLOGY
oaire.citation.volume41
relation.isAuthorOfPublicationbc2327ed-471c-42da-86dd-cef77979cda2
relation.isAuthorOfPublication.latestForDiscoverybc2327ed-471c-42da-86dd-cef77979cda2

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