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Assessment of the Effect of Subthalamic Deep Brain Stimulation on Sleep Quality of Parkinson's Disease Patients

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dc.contributor.authorSÜNTER, GÜLİN
dc.contributor.authorAĞAN YILDIRIM, KADRİYE
dc.contributor.authorGÜNAL, DİLEK
dc.contributor.authorsOner O. G., SÜNTER G., Jafarova S., AĞAN YILDIRIM K., Seker A., GÜNAL D.
dc.date.accessioned2023-06-19T11:23:48Z
dc.date.available2023-06-19T11:23:48Z
dc.date.issued2022-01-01
dc.description.abstractAIM: To investigate the effects of subthalamic deep brain stimulation (STN DBS) therapy on sleep quality of Parkinson\"s Disease (PD) patients and the relationship between sleep, motor symptoms, depression, and adverse effects of dopamine replacement therapies. MATERIAL and METHODS: A total of 26 PD patients have been included and assessed using various tools both 1 week before and 8 months after the STN DBS therapy. The data collection tools were the Unified Parkinson\"s Disease Rating Scale (UPDRS), Beck Depression Inventory (BDI), Montreal Cognitive Assessment (MoCA), Parkinson\"s Disease Questionnaire (PDQ-39), Pittsburgh Sleep Quality Index (PSQI), Insomnia Severity Index (ISI), Epworth Sleepiness Scale (ESS) and Polysomnography. RESULTS: PSQI, ISI, and ESS scores were found to have significantly improved after the STN DBS therapy (p=0.002, p=0.006, p<0.001, respectively), as were the scores obtained from several PSQI sub-scales, that is, sleep duration, sleep disturbance and daytime dysfunction (p=0.023, p=0.005, p=0.032, respectively). Additionally, Wake Times After Sleep Onset (WASO) (p=0.047) and Rapid Eye Movement (REM) sleep latency values (p=0.005) were found to have decreased after the STN DBS treatment, whereas REM sleep durations (p=0,028) and REM sleep percentages (p=0.007) were found to have increased, after the STN DBS therapy. No correlation was found between the ESS scores and Levodopa Equivalent Dosage (LED) or between the scores obtained from the sleep scales and the scores obtained from the UPDRS and BDI. There was also no correlation between sleep scores and other PD-related factors. CONCLUSION: The findings of this study indicated that STN DBS therapy positively affected the PD patients\" sleep. This result was attributed to the neuromodulatory effects of the STN DBS independent of the motor symptoms, depression levels, and LED decrease.
dc.identifier.citationOner O. G., SÜNTER G., Jafarova S., AĞAN YILDIRIM K., Seker A., GÜNAL D., "Assessment of the Effect of Subthalamic Deep Brain Stimulation on Sleep Quality of Parkinson's Disease Patients", TURKISH NEUROSURGERY, cilt.32, sa.3, ss.398-405, 2022
dc.identifier.doi10.5137/1019-5149.jtn.33808-21.2
dc.identifier.endpage405
dc.identifier.issn1019-5149
dc.identifier.issue3
dc.identifier.startpage398
dc.identifier.urihttps://avesis.marmara.edu.tr/api/publication/f773e713-3ba2-4dfb-8164-2401c836e516/file
dc.identifier.urihttps://hdl.handle.net/11424/290413
dc.identifier.volume32
dc.language.isoeng
dc.relation.ispartofTURKISH NEUROSURGERY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectNöroloji
dc.subjectCerrahi Tıp Bilimleri
dc.subjectMedicine
dc.subjectHealth Sciences
dc.subjectInternal Medicine Sciences
dc.subjectNeurology
dc.subjectSurgery Medicine Sciences
dc.subjectKLİNİK NÖROLOJİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectCERRAHİ
dc.subjectCLINICAL NEUROLOGY
dc.subjectCLINICAL MEDICINE
dc.subjectClinical Medicine (MED)
dc.subjectSURGERY
dc.subjectNöroloji (klinik)
dc.subjectCerrahi
dc.subjectYaşam Bilimleri
dc.subjectNeurology (clinical)
dc.subjectSurgery
dc.subjectLife Sciences
dc.subjectSTN-DBS
dc.subjectParkinson?s disease
dc.subjectSleep
dc.subjectGLOBUS-PALLIDUS
dc.subjectNUCLEUS
dc.subjectARCHITECTURE
dc.titleAssessment of the Effect of Subthalamic Deep Brain Stimulation on Sleep Quality of Parkinson's Disease Patients
dc.typearticle
dspace.entity.typePublication
local.avesis.idf773e713-3ba2-4dfb-8164-2401c836e516
local.indexed.atWOS
local.indexed.atPUBMED
local.indexed.atSCOPUS
relation.isAuthorOfPublicatione17c1d30-5cb9-4ec0-921d-407383eed442
relation.isAuthorOfPublication2cdba045-abf1-46b3-ba7f-6b06308d9e57
relation.isAuthorOfPublication35469359-99cb-42f9-9a48-bbe160fee6e2
relation.isAuthorOfPublication.latestForDiscoverye17c1d30-5cb9-4ec0-921d-407383eed442

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