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Topical 8-methoxypsoralen increases the efficacy of narrowband ultraviolet B in psoriasis

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dc.contributor.authorSEÇKİN GENÇOSMANOĞLU, DİLEK
dc.contributor.authorsSeckin, Dilek; Usta, Inan; Yazici, Zuleyha; Senol, Asli
dc.date.accessioned2022-03-12T17:36:09Z
dc.date.available2022-03-12T17:36:09Z
dc.date.issued2009
dc.description.abstractBackground: A combination of oral psoralen with narrowband ultraviolet B (UVB), defined as 'psoralen-narrowband UVB', was shown to have a superior efficacy than UVB alone and even a comparable efficacy to psoralen and ultraviolet A in psoriasis. Objective: To find out whether topical psoralen-narrowband UVB provides any additional benefit to narrowband UVB alone in psoriasis. Methods: Nineteen patients with plaque psoriasis were included. Phototherapy was given three times per week. Two symmetrical lesions were selected as target lesions. in the first 12 sessions of phototherapy, the target lesion on one side was treated with 1% 8-methoxypsoralen (MOP) gel 30 min before UVB radiation whereas the target lesion on the other side served as a control. Target lesion scores were assessed at baseline, third, sixth, ninth and 12th sessions. Side effects were recorded. Results: Sixteen patients completed the Study. Target lesion scores decreased significantly on both sides (P < 0.0001). The mean percentage of decreases was greater on the 8-MOP-applied sides compared with the control sides for all assessments, but the difference was statistically significant only at the ninth session (37.7%, vs. 58.6%, P = 0.043). Pigmentation was frequently seen in 8-MOP gel-applied lesions. Conclusion: Topical 8-MOP gel plus narrowband UVB has greater efficacy than narrowband UVB alone in psoriasis.
dc.identifier.doi10.1111/j.1600-0781.2009.00447.x
dc.identifier.issn0905-4383
dc.identifier.pubmed19747241
dc.identifier.urihttps://hdl.handle.net/11424/229248
dc.identifier.wosWOS:000270357500002
dc.language.isoeng
dc.publisherWILEY-BLACKWELL PUBLISHING, INC
dc.relation.ispartofPHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectmethoxypsoralen
dc.subjectnarrowband ultraviolet B
dc.subjectpsoriasis
dc.subjecttopical
dc.subjecttreatment
dc.subjectPLAQUE-TYPE PSORIASIS
dc.subjectPSORALEN-UVB
dc.subjectPHOTOCHEMOTHERAPY
dc.subjectCOMBINATION
dc.subjectTHERAPY
dc.titleTopical 8-methoxypsoralen increases the efficacy of narrowband ultraviolet B in psoriasis
dc.typearticle
dspace.entity.typePublication
local.avesis.id8578e914-e228-4041-8d70-a94c348403a9
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages5
oaire.citation.endPage241
oaire.citation.issue5
oaire.citation.startPage237
oaire.citation.titlePHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
oaire.citation.volume25
relation.isAuthorOfPublicationacf48150-1ebd-4a7f-8b28-8d8f349ebeed
relation.isAuthorOfPublication.latestForDiscoveryacf48150-1ebd-4a7f-8b28-8d8f349ebeed

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