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Evidence that osteogenic and neurogenic differentiation capability of epidural adipose tissue-derived stem cells was more pronounced than in subcutaneous cells

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dc.contributor.authorŞAHİN, ALİ
dc.contributor.authorsSolmaz, Bilgehan; Sahin, Ali; Kelestemur, Taha; Kilic, Ertugrul; Kaptanoglu, Erkan
dc.date.accessioned2022-04-25T00:11:50Z
dc.date.available2022-04-25T00:11:50Z
dc.date.issued2020
dc.description.abstractBackground/aim: The management of dura-related complications, such as the repairment of dural tears and reconstruction of large dural defects, remain the most challenging subjects of neurosurgery. Numerous surgical techniques and synthetic or autologous adjuvant materials have emerged as an adjunct to primary dural closure, which may result in further complications or side effects. Therefore, the subcutaneous autologous free adipose tissue graft has been recommended for the protection of the central nervous system and repairment of the meninges. In addition, human adipose tissue is also a source of multipotent stem cells. However, epidural adipose tissue seems more promising than subcutaneous because of the close location and intercellular communication with the spinal cord. Herein, it was aimed to define differentiation capability of both subcutaneous and epidural adipose tissue-derived stem cells (ASCs). Materials and methods: Human subcutaneous and epidural adipose tissue specimens were harvested from the primary incisional site and the lumbar epidural space during lumbar spinal surgery, and ASCs were isolated. Results: The results indicated that both types of ASCs expressed the cell surface markers, which are commonly expressed stem cells; however, epidural ASCs showed lower expression of CD90 than the subcutaneous ASCs. Moreover, it was demonstrated that the osteogenic and neurogenic differentiation capability of epidural adipose tissue-derived ASCs was more pronounced than that of the subcutaneous ASCs. Conclusion: Consequently, the impact of characterization of epidural ASCs will allow for a new understanding for dural as well as central nervous system healing and recovery after an injury.
dc.identifier.doi10.3906/sag-2001-76
dc.identifier.eissn1303-6165
dc.identifier.issn1300-0144
dc.identifier.pubmed32222128
dc.identifier.urihttps://hdl.handle.net/11424/263976
dc.identifier.wosWOS:000600735500010
dc.languageeng
dc.publisherTUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY
dc.relation.ispartofTURKISH JOURNAL OF MEDICAL SCIENCES
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectEpidural adipose tissue
dc.subjectstem cell
dc.subjectdifferentiation
dc.subjectCD90
dc.subjectCD105
dc.subjectFAT
dc.subjectADIPOCYTES
dc.subjectPARTICIPATE
dc.subjectEXPRESSION
dc.subjectGENERATION
dc.subjectORIGINS
dc.subjectCULTURE
dc.titleEvidence that osteogenic and neurogenic differentiation capability of epidural adipose tissue-derived stem cells was more pronounced than in subcutaneous cells
dc.typearticle
dspace.entity.typePublication
local.avesis.id61e27b72-be0a-4ba3-826c-a0c99d5c67c0
local.import.packageSS39
local.indexed.atWOS
local.journal.numberofpages13
local.journal.quartileQ4
oaire.citation.endPage1837
oaire.citation.issue8
oaire.citation.startPage1825
oaire.citation.titleTURKISH JOURNAL OF MEDICAL SCIENCES
oaire.citation.volume50
relation.isAuthorOfPublicationdda71138-8ce4-4265-89b2-73bc94786a4f
relation.isAuthorOfPublication.latestForDiscoverydda71138-8ce4-4265-89b2-73bc94786a4f

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