Publication:
Protective effect of bromelain on corrosive burn in rats

Simple item page
dc.contributor.authorVELİOĞLU ÖĞÜNÇ, AYLİZ
dc.contributor.authorsSehirli, Ahmet Ozer; Sayiner, Serkan; Savtekin, Gokce; Velioglu-Ogunc, Ayliz
dc.date.accessioned2022-03-12T22:56:57Z
dc.date.available2022-03-12T22:56:57Z
dc.date.issued2021
dc.description.abstractIntroduction: In some cases, the tongue and oesophagus tissues are damaged by the corrosive burn. Surgical interventions may cause scar formation, and severe burns treatment methods are limited. This study aims to investigate bromelain, a phytotherapeutic product, on the corrosive burn as a non-surgical option and as an adjunctive therapy, insofar as the treatment of corrosive wounds is not limited only to the treatment of oxidative stress and inflammatory reactions. Methods: On the tongues of Wistar albino rats, chemically produced oral ulcers were created by topical application of NaOH (40%) solution, and in the distal oesophagus same mixture was applied to produce a corrosive oesophageal burn. For a week, they were treated orally by bromelain (100 mg/kg/day) or saline solution. At the end of seven days, animals were decapitated to remove the tongue and oesophagus, and blood samples were collected to obtain serum. Myeloperoxidase (MPO) activity, malondialdehyde (MDA), glutathione (GSH), interleukin-1 beta (IL-1 beta) and tumour necrosis factor-alpha (TNF-alpha) concentrations were measured in serum, and luminol and lucigenin chemiluminescence (CL) were measured in tissue samples. Results: MDA and CL values were significantly increased, and GSH levels in tissue significantly decreased due to the corrosive burns. Saline treated corrosive burn group measured higher in the serum cytokines in according to the control group. Conclusions: Bromelain administration decreased oxidant and inflammatory parameters and increased antioxidant levels in NaOH-induced corrosive burns. Thus, we concluded that bromelain may protect the tongue and oesophagus tissues with its anti-inflammatory and antioxidant effects. (C) 2020 Elsevier Ltd and ISBI. All rights reserved.
dc.identifier.doi10.1016/j.burns.2020.12.006
dc.identifier.eissn1879-1409
dc.identifier.issn0305-4179
dc.identifier.pubmed33934907
dc.identifier.urihttps://hdl.handle.net/11424/236981
dc.identifier.wosWOS:000691216600015
dc.language.isoeng
dc.publisherELSEVIER SCI LTD
dc.relation.ispartofBURNS
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBromelain
dc.subjectCorrosive burn
dc.subjectOesophagus
dc.subjectInflammation
dc.subjectTongue
dc.subjectSTRICTURE FORMATION
dc.subjectOXIDATIVE STRESS
dc.subjectINJURY
dc.titleProtective effect of bromelain on corrosive burn in rats
dc.typearticle
dspace.entity.typePublication
local.avesis.id17d09c12-93b6-4e54-8ef9-2e7f45711df6
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages7
oaire.citation.endPage1358
oaire.citation.issue6
oaire.citation.startPage1352
oaire.citation.titleBURNS
oaire.citation.volume47
relation.isAuthorOfPublication13300bf6-ba96-4f87-9868-b0d2c86f572a
relation.isAuthorOfPublication.latestForDiscovery13300bf6-ba96-4f87-9868-b0d2c86f572a

Files

Collections

Research Outputs