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Osteoporosis: An ignored complication of CVID

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dc.contributor.authorÖZEN, AHMET OĞUZHAN
dc.contributor.authorsBaris, Safa; Ozen, Ahmet; Ercan, Hulya; Karakoc-Aydiner, Elif; Cagan, Hasret; Ozdemir, Cevdet; Barlan, Metin; Bahceciler, Nerin N.; Barlan, Isil B.
dc.date.accessioned2022-03-12T18:04:52Z
dc.date.available2022-03-12T18:04:52Z
dc.date.issued2011
dc.description.abstractBackground: Multiple factors in common variable immunodeficiency (CVID) might interfere with optimal growth and maturation and potentially compromise bone health. Methods: We aimed to evaluate bone mineral density (BMD) of patients with CVID using dual energy X-ray absorptiometry (DEXA) and investigate risk factors associated with decreased bone density. Results: Twenty-two patients were included (M: 16, F: 6) with a mean age of 15.6 +/- 9.0 yr. DEXA revealed osteopenia in 6/22 (27.3%) and osteoporosis in 9/22 (40.9%) at lumbar spine and osteopenia in 7/19 (37%) and osteoporosis in 3/19 (16%) at femoral neck sites. The age of subjects with osteoporosis was significantly higher than those without (21.6 +/- 8.0 vs. 9.0 +/- 5.7 yr; p < 0.0001). BMD z-scores were significantly lower in patients with bronchiectasis compared with those without (p = 0.03). Patients with osteoporosis at femoral neck site had lower forced expiratory volume in 1 s (FEV1) (p = 0.024), FEV1/forced vital capacity (FVC) (p < 0.0001), PEF (p = 0.008), and FEF 25-75 (p = 0.013) values compared with the patients with normal BMD z-scores. Low serum 25(OH) vitamin D levels were detected in 13/22 patients and low dietary calcium intake in 17/22 patients. BMD z-scores at femoral neck were lower in patients with low B-cell percentage (p = 0.03). BMD z-score at lumbar spine was correlated with folate (r = +0.63, p = 0.004) and serum immunoglobulin G levels (r = +0.430, p = 0.04). Conclusion: Osteoporosis appeared as an emerging health problem of patients with CVID, the risk increasing with older age and poorer lung function. Nutritional, biochemical, and immunologic factors appeared to take part in decreased BMD. Insight into the mechanisms of osteoporosis in CVID is crucial to develop preventive strategies.
dc.identifier.doi10.1111/j.1399-3038.2011.01187.x
dc.identifier.eissn1399-3038
dc.identifier.issn0905-6157
dc.identifier.pubmed21645119
dc.identifier.urihttps://hdl.handle.net/11424/230496
dc.identifier.wosWOS:000295137100006
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofPEDIATRIC ALLERGY AND IMMUNOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectcommon variable immunodeficiency
dc.subjectosteoporosis
dc.subjectchronic lung disease
dc.subjectfolate
dc.subjectBONE-MINERAL DENSITY
dc.subjectCOMMON VARIABLE IMMUNODEFICIENCY
dc.subjectCYSTIC-FIBROSIS
dc.subjectPEDIATRIC-PATIENTS
dc.subjectVITAMIN-D
dc.subjectWOMEN
dc.subjectHOMOCYSTEINE
dc.subjectMETABOLISM
dc.subjectINFECTION
dc.subjectCHILDREN
dc.titleOsteoporosis: An ignored complication of CVID
dc.typearticle
dspace.entity.typePublication
local.avesis.idcc6f582f-e455-4eb3-bef8-4afda43d26d6
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages8
oaire.citation.endPage683
oaire.citation.issue7
oaire.citation.startPage676
oaire.citation.titlePEDIATRIC ALLERGY AND IMMUNOLOGY
oaire.citation.volume22
relation.isAuthorOfPublication3e9c297b-e636-4836-8f61-dc9c8b7c29cf
relation.isAuthorOfPublication.latestForDiscovery3e9c297b-e636-4836-8f61-dc9c8b7c29cf

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