Publication:
THERAPEUTIC POTENTIAL OF MYRTUS COMMUNIS SUBSP COMMUNIS EXTRACT AGAINST ACETIC ACID-INDUCED COLONIC INFLAMMATION IN RATS

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dc.contributor.authorŞEN, ALİ
dc.contributor.authorsSen, Ali; Yuksel, Meral; Bulut, Gizem; Bitis, Leyla; Ercan, Feriha; Ozyilmaz-Yay, Nagehan; Akbulut, Ozben; Cobanoglu, Hamit; Ozkan, Sevil; Sener, Goksel
dc.date.accessioned2022-03-12T22:23:40Z
dc.date.available2022-03-12T22:23:40Z
dc.date.issued2017
dc.description.abstractThe aim of this study was to evaluate the effect of ethanol extract from leaves of Myrtus communis subsp. communis (MC) on acetic acid (AA)-induced ulcerative colitis in rats. On the fourth day of colitis induction, all rats were decapitated. Colitis was assessed by macroscopic and microscopic scores and by measuring malondialdehyde (MDA) and glutathione (GSH) levels, myeloperoxidase (MPO) activity, luminol, lucigenin, nitric oxid and peroxynitrite chemiluminescence (CL). Colitis caused significant increases in the colonic MDA levels, MPO activity, CL values, macroscopic and microscopic damage scores along with significant decrease in tissue GSH level. However, treatment with MC extract reversed all these biochemical indices, as well as histopathological alterations induced by AA with the protective effects being similar to that of sulphasalazine treatment. The study showed that MC extract could alleviate colitis in rats and can be considered an alternative therapeutic approach for management of inflammatory bowel diseases (IBD).
dc.identifier.doi10.1111/jfbc.12297
dc.identifier.eissn1745-4514
dc.identifier.issn0145-8884
dc.identifier.urihttps://hdl.handle.net/11424/234507
dc.identifier.wosWOS:000397284000024
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofJOURNAL OF FOOD BIOCHEMISTRY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectINDUCED COLITIS
dc.subjectULCERATIVE-COLITIS
dc.subjectBOWEL-DISEASE
dc.subjectNITRIC-OXIDE
dc.subjectIN-VIVO
dc.subjectANTIOXIDANT ACTIVITY
dc.subjectDEPENDENT MECHANISM
dc.subjectRESPIRATORY BURST
dc.subjectREACTIVE OXYGEN
dc.subjectMYELOPEROXIDASE
dc.titleTHERAPEUTIC POTENTIAL OF MYRTUS COMMUNIS SUBSP COMMUNIS EXTRACT AGAINST ACETIC ACID-INDUCED COLONIC INFLAMMATION IN RATS
dc.typearticle
dspace.entity.typePublication
local.avesis.ida0f1a1b2-048f-4188-bbde-29dff264d19e
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.articlenumbere12297
local.journal.numberofpages10
local.journal.quartileQ3
oaire.citation.issue1
oaire.citation.titleJOURNAL OF FOOD BIOCHEMISTRY
oaire.citation.volume41
relation.isAuthorOfPublication9e088078-d757-41a4-afc6-909f32031cb1
relation.isAuthorOfPublication.latestForDiscovery9e088078-d757-41a4-afc6-909f32031cb1

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