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Interaction between C-Reactive Protein and Endothelin-1 in Coronary Artery Disease

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dc.contributor.authorFAK, ALİ SERDAR
dc.contributor.authorsGemici, Goekmen; Erdim, Refik; Tokay, Sena; Tezcan, Hakan; Fak, A. Serdar; Oktay, Ahmet
dc.date.accessioned2022-03-12T17:32:14Z
dc.date.available2022-03-12T17:32:14Z
dc.date.issued2007
dc.description.abstractBackground: Increased concentrations of serum C-reactive protein (CRP) have been reported to predict major cardiovascular events in patients with coronary artery disease (CAD). Increased concentrations of endothelin-1 (ET-1) are also associated with poor prognosis after myocardial infarction. Hypothesis: We tested the hypothesis that ET-1 might contribute to CRP in prediction of adverse outcome in CAD. Methods: Serum high sensitive CRP and plasma ET-1 levels of 40 patients who have stable CAD and 25 control subjects were measured, and correlation analysis between these molecules was performed. Results: Mean high sensitive CRP was 8.64 +/- 12.73 mg/l, and mean ET-1 was 8.24 +/- 7.06 pg/ml in the CAD group. We found that there was no statistically significant correlation between high sensitive CRP and ET-1 in either CAD group (p = 0.82), or the control group (p = 0.85). In a subgroup of 13 patients who were not under statin treatment, we found a strong correlation between the levels of these molecules (p = 0.01). Conclusion: Our study does not clearly support or exclude a link between CRP and ET-1 in patients who have stable CAD. Copyright (C) 2007 S. Karger AG, Basel
dc.identifier.doi10.1159/000099048
dc.identifier.eissn1421-9751
dc.identifier.issn0008-6312
dc.identifier.pubmed17283423
dc.identifier.urihttps://hdl.handle.net/11424/228514
dc.identifier.wosWOS:000206881800010
dc.language.isoeng
dc.publisherKARGER
dc.relation.ispartofCARDIOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAtherosclerosis
dc.subjectCoronary artery disease
dc.subjectC-reactive protein
dc.subjectEndothelin-1
dc.subjectStatin
dc.titleInteraction between C-Reactive Protein and Endothelin-1 in Coronary Artery Disease
dc.typearticle
dspace.entity.typePublication
local.avesis.id0630dd1d-deb5-4ba4-ab5d-7e2f6f8c6dc5
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages5
oaire.citation.endPage344
oaire.citation.issue4
oaire.citation.startPage340
oaire.citation.titleCARDIOLOGY
oaire.citation.volume107
relation.isAuthorOfPublication7fadb6bf-c4a2-4220-9c4e-367d520e3c98
relation.isAuthorOfPublication.latestForDiscovery7fadb6bf-c4a2-4220-9c4e-367d520e3c98

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