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Protective effect of low dose caffeine on psychological stress and cognitive function

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dc.contributor.authorAKAKIN, DİLEK
dc.contributor.authorsCakir, Ozgur Kasimay; Ellek, Nurfitnat; Salehin, Nabila; Hamamci, Rabia; Keles, Hulya; Kayali, Damla Gokceoglu; Akakin, Dilek; Yuksel, Meral; Ozbeyli, Dilek
dc.date.accessioned2022-03-12T20:31:34Z
dc.date.available2022-03-12T20:31:34Z
dc.date.issued2017
dc.description.abstractIntroduction: Caffeine is an adrenergic antagonist that enhances neuronal activity. Psychological stress depresses cognitive function. Aim: To investigate the effects of acute and chronic low dose caffeine on anxiety-like behavior and cognitive functions of acute or chronic psychological stressed rats. Material-method: Acute or chronic caffeine (3 mg/kg) was administered to male Sprague Dawley rats (200-250 g, n = 42) before acute (cat odor) and chronic variable psychological stress (restraint overcrowding stress, elevated plus maze, cat odor, forced swimming) induction. Anxiety and cognitive functions were evaluated byhole-board and object recognition tests. The brain glutathione and malondialdehyde assays, myeloperoxidase, nitric oxide (NO), superoxide dismutase (SOD), luminol and lucigenin activity and histological examination were done. ANOVA and Student's t-test were used for statistical analysis. Results: The depressed cognitive function with chronic stress exposure and the increased anxiety-like behavior with both stress inductions were improved via both caffeine applications (p < 0.05-0.001). Both caffeine pretreatments in chronic stressed rats, and chronic caffeine in acute stressed ones reduced the elevated myeloperoxidase activities (p < 0.05-0.01). The increased malondialdehyde, lucigenin and NO levels with acute stress were inhibited with chronic caffeine (p < 0.05-0.01), malondialdehyde and NO levels were declined by acute caffeine (p < 0.001). Acute caffeine decreased SOD activity (p < 0.01) and improved glutathione (p < 0.01) and luminol levels (p < 0.05). The induced histological damage with both stress exposures was ameliorated with chronic caffeine. Conclusion: The increased anxiety-like behavior and depleted cognitive functions under stress conditions were improved with both acute and predominantly chronic caffeine pretreatments by decreasing oxidative damage parameters. (C) 2016 Elsevier Inc. All rights reserved.
dc.identifier.doi10.1016/j.physbeh.2016.10.010
dc.identifier.issn0031-9384
dc.identifier.pubmed27746260
dc.identifier.urihttps://hdl.handle.net/11424/234304
dc.identifier.wosWOS:000390511400001
dc.language.isoeng
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.relation.ispartofPHYSIOLOGY & BEHAVIOR
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectWorking memory
dc.subjectOxidative damage
dc.subjectAcute stress
dc.subjectChronic stress
dc.subjectAnxiety
dc.subjectNITRIC-OXIDE PRODUCTION
dc.subjectACUTE RESTRAINT STRESS
dc.subjectOXIDATIVE STRESS
dc.subjectINDUCED ANXIETY
dc.subjectRATS
dc.subjectINFLAMMATION
dc.subjectANTIOXIDANT
dc.subjectADENOSINE
dc.subjectSYSTEM
dc.subjectDAMAGE
dc.titleProtective effect of low dose caffeine on psychological stress and cognitive function
dc.typearticle
dspace.entity.typePublication
local.avesis.idc541bfb1-5c4a-4dae-875e-4b06b7a9c51a
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages10
local.journal.quartileQ2
oaire.citation.endPage10
oaire.citation.startPage1
oaire.citation.titlePHYSIOLOGY & BEHAVIOR
oaire.citation.volume168
relation.isAuthorOfPublicationc97c0ebf-ffce-4b27-a933-941a53767b0d
relation.isAuthorOfPublication.latestForDiscoveryc97c0ebf-ffce-4b27-a933-941a53767b0d

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