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The effects of Origanum onites in streptozotocin-induced diabetes mellitus in rats

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dc.contributor.authorPOLAT, ELİF BEYZANUR
dc.contributor.authorTAŞKIN, TURGUT
dc.contributor.authorBİTİŞ, LEYLA
dc.contributor.authorELÇİOĞLU, HATİCE KÜBRA
dc.contributor.authorsAydemir O., Polat E. B. , Aljesri K., TAŞKIN T., BİTİŞ L., ELÇİOĞLU H. K.
dc.date.accessioned2022-12-19T10:45:32Z
dc.date.available2022-12-19T10:45:32Z
dc.date.issued2022-01-01
dc.description.abstract© 2022 Marmara University Press.Diabetes mellitus is a chronic disease characterized by decreased insulin synthesis and/or increased blood glucose due to insulin resistance. In this study, streptozotocin (STZ)-induced diabetic rats were evaluated and it was aimed to investigate the protective effects of Origanum onites L. (OO) against possible changes in these parameters. Male Sprague-Dawley rats weighing 300-400g were divided into three groups control (C), diabetes mellitus (DM) and diabetes mellitus + OO (OO group). DM was induced by administration of STZ 60 mg/kg dose intraperitoneally (i.p.) after 48 hours, rats with blood glucose values higher than 200 mg/dL were considered DM. Origanum extract was administered i.p. to the OO group at 50 mg/kg per day for 6 weeks. Serum AST, ALT, creatinine, and inflammatory cytokine levels were measured. MDA and GSH levels were measured in liver tissues. AST, ALT, creatinine, and MDA levels were found to be increased in the DM group, while a significant decrease in these levels was observed in the treated group. While GSH values fell in the DM group, a significant increase occurred in the OO group (n=6, p<0.0001; two-way ANOVA). When the plasma levels of cytokines were examined, an increase was observed in the DM group and a significant decrease was observed in the OO group. When we evaluate our findings, we think that OO has a protective effect against complications that may occur in DM by preventing oxidant damage and inflammation. Further studies are needed on the protective effects of OO in DM.
dc.identifier.citationAydemir O., Polat E. B. , Aljesri K., TAŞKIN T., BİTİŞ L., ELÇİOĞLU H. K. , "The effects of Origanum onites in streptozotocin-induced diabetes mellitus in rats", Journal of Research in Pharmacy, cilt.26, sa.6, ss.1884-1892, 2022
dc.identifier.doi10.29228/jrp.278
dc.identifier.endpage1892
dc.identifier.issn2630-6344
dc.identifier.issue6
dc.identifier.startpage1884
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85142152754&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/283699
dc.identifier.volume26
dc.language.isoeng
dc.relation.ispartofJournal of Research in Pharmacy
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTemel Eczacılık Bilimleri
dc.subjectEczacılık
dc.subjectYaşam Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectTemel Bilimler
dc.subjectBasic Pharmaceutics Sciences
dc.subjectPharmacology and Therapeutics
dc.subjectLife Sciences
dc.subjectHealth Sciences
dc.subjectNatural Sciences
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectLife Sciences (LIFE)
dc.subjectPHARMACOLOGY & TOXICOLOGY
dc.subjectPHARMACOLOGY & PHARMACY
dc.subjectGenel Farmakoloji, Toksikoloji ve Eczacılık
dc.subjectFarmakoloji (tıbbi)
dc.subjectGeneral Pharmacology, Toxicology and Pharmaceutics
dc.subjectPharmacology (medical)
dc.subjectDiabetes mellitus
dc.subjectinflammatory cytokine
dc.subjectliver
dc.subjectOriganum onites
dc.subjectoxidative stress
dc.subjectDiabetes mellitus
dc.subjectoxidative stress
dc.subjectliver
dc.subjectOriganum onites
dc.subjectinflammatory cytokine
dc.titleThe effects of Origanum onites in streptozotocin-induced diabetes mellitus in rats
dc.typearticle
dspace.entity.typePublication
local.avesis.id41954f8c-7729-43e6-845b-3d498a3c54b5
local.indexed.atSCOPUS
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relation.isAuthorOfPublication.latestForDiscoveryd31c78d9-42ce-4ff3-abfb-c0956bfb6a0b

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