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Taurine ameliorates stress-induced degeneration of the urinary bladder

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dc.contributor.authorERCAN, FERİHA
dc.contributor.authorsZeybek, Ali; Saglam, Beyhan; Cikler, Esra; Cetinel, Sule; Ercan, Feriha; Sener, Goksel
dc.date.accessioned2022-03-12T17:32:43Z
dc.date.available2022-03-12T17:32:43Z
dc.date.issued2007
dc.description.abstractWe studied the potential effects of taurine, a free radical scavenger, on chronic water avoidance stress (WAS)-induced degeneration of the mucosa of the urinary bladder in experimental rats. Wistar albino rats were exposed to WAS for 2 h/day, for 5 days (WAS group). Before exposing them to WAS, taurine (50 mg/kg) (WAS+taurine group) was injected intraperitonally into the animals. Samples of urinary bladder were then investigated by light and scanning electron microscopy. Lipid peroxidation and gluthathione levels were also measured in the urinary bladder. In the WAS-only group, inflammatory cell infiltration, increased number of mast cells in the mucosa and ulcerated areas were observed. In the WAS+taurine group, relatively normal urothelial topography with microvilli, moderate inflammatory cell infiltration and decreased numbers of mast cells in the mucosa were observed. The increased lipid peroxidation and decreased glutathione levels in WAS rats were reversed by taurine treatment. We conclude that taurine protects against WAS-induced oxidant urinary bladder injury, and thus may be a possible therapeutic agent against interstitial cystitis, the symptoms of which are aggravated by stress conditions. (c) 2006 Elsevier GmbH. All rights reserved.
dc.identifier.doi10.1016/j.acthis.2006.12.001
dc.identifier.issn0065-1281
dc.identifier.pubmed17287017
dc.identifier.urihttps://hdl.handle.net/11424/228668
dc.identifier.wosWOS:000247461200006
dc.language.isoeng
dc.publisherELSEVIER GMBH, URBAN & FISCHER VERLAG
dc.relation.ispartofACTA HISTOCHEMICA
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectinterstitial cystitis
dc.subjectmast cells
dc.subjectmicroscopy
dc.subjectrats
dc.subjecttaurine
dc.subjectwater avoidance
dc.subjectstress
dc.subjectINTERSTITIAL CYSTITIS
dc.subjectMAST-CELLS
dc.subjectIN-VITRO
dc.subjectRATS
dc.subjectACTIVATION
dc.subjectBARRIER
dc.subjectKIDNEY
dc.subjectINJURY
dc.subjectVIVO
dc.titleTaurine ameliorates stress-induced degeneration of the urinary bladder
dc.typearticle
dspace.entity.typePublication
local.avesis.id9e9a7010-f118-4c75-9d78-b96a3f357533
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages7
oaire.citation.endPage214
oaire.citation.issue3
oaire.citation.startPage208
oaire.citation.titleACTA HISTOCHEMICA
oaire.citation.volume109
relation.isAuthorOfPublicationadc800ed-105c-40c7-a572-6cf3f175be92
relation.isAuthorOfPublication.latestForDiscoveryadc800ed-105c-40c7-a572-6cf3f175be92

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