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Protective effects of quercetin against cisplatin induced urogenital organ toxicity

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dc.contributor.authorERCAN, FERİHA
dc.contributor.authorsSener, Tarik Emre; Cadirci, Selin; Cevik, Ozge; Ercan, Feriha; Koroglu, M. Kutay; Sakarcan, Selin; Sener, Goksel
dc.date.accessioned2022-03-14T09:24:37Z
dc.date.available2022-03-14T09:24:37Z
dc.date.issued2020-09-11
dc.description.abstractCisplatin is a chemotherapeutic agent that is the first to enter treatment from organic platinum-derived drugs. Nephrotoxicity and cytotoxicity are major factors that limit its use. The aim of the study is to investigate the possible protective effects of quercetin against cisplatin-induced urogenital organ toxicity. In our study, Sprague Dawley four month old male rats were divided into 4 groups; control + saline (SF), control + quercetin (20 mg/kg for 21 days), cisplatin (7 mg/kg as a single dose) + SF and cisplatin + quercetin groups. After decapitation, the kidney, bladder, testis and corpus cavernosum tissue samples were taken to analyze caspase-3, an index of apoptosis, and oxidative stress parameters such as malondialdehyde (MDA), gluta-thione (GSH), and 8-hydroxy-2'-deoxyguanosine (8-OHdG). Furthermore, tissues were also examined histologically. Cisplatin caused significant increases in MDA and 8-OHdG levels, demonstrating increases in lipid peroxidation and oxidative DNA damage, respectively, in all tissues. In parallel with the oxidant stress increase, the endogenous strong antioxidant GSH levels were decreased. Caspase activity and caspase 3 expressions, which we measured as an indicator of apoptosis, increased significantly with cisplatin treatment. On the other hand, treatment with quercetin, a powerful antioxidant flavonoid, reversed these changes. Histological findings also demonstrated well-preserved tissues due to quercetin treatment. In conclusion, our results suggested that quercetin, when given with cisplatin, can be protective against the chemotherapeutic induced toxicity and thus provide therapeutic benefit.
dc.identifier.doi10.35333/jrp.2020.219
dc.identifier.issn2630-6344
dc.identifier.urihttps://hdl.handle.net/11424/243084
dc.identifier.wosWOS:000570795700005
dc.language.isoeng
dc.publisherMARMARA UNIV
dc.relation.ispartofJOURNAL OF RESEARCH IN PHARMACY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCisplatin
dc.subjectoxidative stress
dc.subjectquercetin
dc.subjectbladder
dc.subjectkidney
dc.subjecttestis
dc.subjectcorpus cavernosum
dc.subjectINJURY
dc.subjectNEPHROTOXICITY
dc.subjectMELATONIN
dc.subjectSTRESS
dc.titleProtective effects of quercetin against cisplatin induced urogenital organ toxicity
dc.typearticle
dspace.entity.typePublication
local.avesis.id89be1bc4-61fe-41bd-8728-b0639b26e5a2
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atTRDIZIN
local.journal.numberofpages8
oaire.citation.endPage647
oaire.citation.issue5
oaire.citation.startPage640
oaire.citation.titleJOURNAL OF RESEARCH IN PHARMACY
oaire.citation.volume24
relation.isAuthorOfPublicationadc800ed-105c-40c7-a572-6cf3f175be92
relation.isAuthorOfPublication.latestForDiscoveryadc800ed-105c-40c7-a572-6cf3f175be92

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