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Cyclosporine-A induced nephrotoxicity is associated with decreased renal bone morphogenetic protein-7 expression in rats

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dc.contributor.authorYAVUZ, DİLEK
dc.contributor.authorsTuglular, S; Yavuz, DG; Cakalagaoglu, F; Citak, L; Arikan, H; Kocak, H; Ozener, C; Akoglu, E
dc.date.accessioned2022-03-12T15:58:33Z
dc.date.available2022-03-12T15:58:33Z
dc.date.issued2004
dc.description.abstractThe aim of our study was to investigate bone morphogenetic protein-7 (BMP-7) expression in a rat model of chronic cyclosporine (CsA) toxicity compare with healthy controls, as well as the influence of treatment with the angiotensin-converting enzyme inhibitor (ACEI) quinapril. Twenty-four male Wistar rats were divided into groups of eight animals treated with CsA (15 mg/kg intraperitoneally) for 8 weeks (CsA group) without or with quinapril (10 mg/kg per day in the drinking water: CsA group + Q) for comparison with healthy controls (H group). The renal tissues were examined by light microscopy for CsA toxicity; specifically, tubulointerstitial damage and afferent arteriolopathy as well as BMP-7 expression were serniquantitatively scored by immunohistochemical staining. Mean CsA levels were 1982 ng/mL and 1968 ng/mL for the CsA and CsA + Q groups, respectively. At the end of the study period, the mean serum creatinine levels were 0.8 +/- 0.2 mg/dL, 1.6 +/- 0.8 mg/dL, and 1.4 +/- 0.8 mg/dL for the H, CsA, and CsA + Q groups, respectively. Interstitial fibrosis, tubular atrophy, and afferent arteriolar hyalinization were present in the CsA group and, to a lesser degree, in the CsA + Q group, compared with the H group. CsA-treated rats displayed significantly decreased BMP-7 expression compared with healthy controls (P < .0005). BMP-7 expression was higher among the CsA + Q group than the the group CsA group. In a rat model histologic changes characteristic of CsA-induced nephrotoxicity are associated with decreased expression of BMP-7, which seems to be at least partially restored by ACE inhibition.
dc.identifier.doi10.1016/j.transproceed.2003.11.018
dc.identifier.eissn1873-2623
dc.identifier.issn0041-1345
dc.identifier.pubmed15013323
dc.identifier.urihttps://hdl.handle.net/11424/224089
dc.identifier.wosWOS:000188758100039
dc.language.isoeng
dc.publisherELSEVIER SCIENCE INC
dc.relation.ispartofTRANSPLANTATION PROCEEDINGS
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.titleCyclosporine-A induced nephrotoxicity is associated with decreased renal bone morphogenetic protein-7 expression in rats
dc.typeconferenceObject
dspace.entity.typePublication
local.avesis.idd64739c8-4e8e-45e5-86a5-97a6209f17bf
local.conference.dateJUN 25-27, 2003
local.conference.locationANKARA, TURKEY
local.conference.sponsorTurkish Transplantat Soc, Eurotransplant
local.conference.titleJoint Meeting of the Turkish-Transplantation-Society and Eurotransplant
local.import.packageSS15
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages3
oaire.citation.endPage133
oaire.citation.issue1
oaire.citation.startPage131
oaire.citation.titleTRANSPLANTATION PROCEEDINGS
oaire.citation.volume36
relation.isAuthorOfPublication26174ec5-7dca-4038-a7fe-9a43f236fd15
relation.isAuthorOfPublication.latestForDiscovery26174ec5-7dca-4038-a7fe-9a43f236fd15

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