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An Adolescent with Hyperimmunoglobulinemia D and Periodic Fever Syndrome Responding to Simvastatin Treatment

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dc.contributor.authorAYDINER, ELİF
dc.contributor.authorsKarakoc-Aydiner, Elif; Ozdemir, Cevdet; Keles, Sevgi; Baris, Safa; Bahceciler, Nerin N.; Barlan, Isil B.
dc.date.accessioned2022-03-14T10:01:08Z
dc.date.available2022-03-14T10:01:08Z
dc.date.issued2011-06-15
dc.description.abstractThe hyperimmunoglobulinemia D and periodic fever syndrome is proposed to be caused by a defect in the activity of mevalonate kinase enzyme which is involved in cholesterol and non-sterol isoprenoid biosynthesis. This autosomal recessive inherited auto-inflammatory syndrome is characterized by recurrent fever attacks, abdominal pain, lymphadenopathy, skin lesions and joint involvement. In this article, we present our therapeutic approach with the hypolipidemic agent, simvastatin, in a 12-year-old boy followed up with a diagnosis of hyperimmunoglobulinemia D and periodic fever syndrome. Simvastatin treatment of an adolescent with hyperimmunoglobulinemia D and periodic fever syndrome unresponsive to anti-inflammatory strategies has resulted in a favorable outcome. This treatment is thought to reduce the recurrent fever attacks by reducing the mevalonic acid increase or isopreniod shortage.
dc.identifier.doi10.5152/tjr.2011.026
dc.identifier.issn1309-0291
dc.identifier.urihttps://hdl.handle.net/11424/243903
dc.identifier.wosWOS:000295972800013
dc.language.isoeng
dc.publisherTURKISH LEAGUE AGAINST RHEUMATISM
dc.relation.ispartofTURKISH JOURNAL OF RHEUMATOLOGY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHyperimmunoglobulinemia D
dc.subjectperiodic fever syndrome
dc.subjectsimvastatin
dc.subjectMEVALONATE KINASE-DEFICIENCY
dc.subjectHYPER-IGD
dc.subjectISOPRENOID BIOSYNTHESIS
dc.subjectFOLLOW-UP
dc.subjectMUTATIONS
dc.subjectATTACKS
dc.subjectSERIES
dc.subjectCELLS
dc.titleAn Adolescent with Hyperimmunoglobulinemia D and Periodic Fever Syndrome Responding to Simvastatin Treatment
dc.typearticle
dspace.entity.typePublication
local.avesis.id68b90ece-30d5-4d54-9f76-5fb3e502bb81
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atTRDIZIN
local.journal.numberofpages4
oaire.citation.endPage170
oaire.citation.issue2
oaire.citation.startPage167
oaire.citation.titleTURKISH JOURNAL OF RHEUMATOLOGY
oaire.citation.volume26
relation.isAuthorOfPublication787c2629-584b-4b3e-9850-bf85838f2973
relation.isAuthorOfPublication.latestForDiscovery787c2629-584b-4b3e-9850-bf85838f2973

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