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Synthesis and characterization of antibacterial drug loaded beta-tricalcium phosphate powders for bone engineering applications

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dc.contributor.authorOKTAR, FAİK NÜZHET
dc.contributor.authorsTopsakal, Aysenur; Ekren, Nazmi; Kilic, Osman; Oktar, Faik N.; Mahirogullari, Mahir; Ozkan, Ozan; Sasmazel, Hilal Turkoglu; Turk, Mustafa; Bogdan, Iuliana M.; Stan, George E.; Gunduz, Oguzhan
dc.date.accessioned2022-03-12T22:54:50Z
dc.date.available2022-03-12T22:54:50Z
dc.date.issued2020
dc.description.abstractPowders of beta-tricalcium phosphate [beta-TCP, beta-Ca-3(PO4)(2)] and composite powders of beta-TCP and polyvinyl alcohol (PVA) were synthesized by using wet precipitation methods. First, the conditions for the preparation of single phase beta-TCP have been delineated. In the co-precipitation procedure, calcium nitrate and diammonium hydrogen phosphate were used as calcium and phosphorous precursors, respectively. The pH of the system was varied in the range 7-11 by adding designed amounts of ammonia solution. The filtered cakes were desiccated at 80 degrees C and subsequently calcined at different temperatures in the range between 700-1100 degrees C. Later on, rifampicin form II was used to produce drug-loaded beta-TCP and PVA/beta-TCP powders. All the synthesized materials have been characterized from morphological (by scanning electron microscopy) and structural-chemical (by X-ray diffraction and Fourier transform infrared spectroscopy) point of view. The drug loading capacity of the selected pure beta-TCP powder has been assessed. The biological performance (cytocompatibility in fibroblast cell culture and antibacterial efficacy against Escherichia coli and Staphylococcus aureus) has been tested with promising results. Application perspectives of the designed drug-bioceramic-polymer blends are advanced and discussed. [GRAPHICS] .
dc.identifier.doi10.1007/s10856-019-6356-1
dc.identifier.eissn1573-4838
dc.identifier.issn0957-4530
dc.identifier.pubmed31965360
dc.identifier.urihttps://hdl.handle.net/11424/236543
dc.identifier.wosWOS:000513866000006
dc.language.isoeng
dc.publisherSPRINGER
dc.relation.ispartofJOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectIN-VITRO
dc.subjectCALCIUM PYROPHOSPHATE
dc.subjectANTIMICROBIAL ACTIVITY
dc.subjectBIOLOGICAL-PROPERTIES
dc.subjectMECHANICAL-PROPERTIES
dc.subjectJOINT INFECTIONS
dc.subjectSOLID-STATE
dc.subjectRIFAMPICIN
dc.subjectHYDROXYAPATITE
dc.subjectNANOPARTICLES
dc.titleSynthesis and characterization of antibacterial drug loaded beta-tricalcium phosphate powders for bone engineering applications
dc.typearticle
dspace.entity.typePublication
local.avesis.id3e8d3b7e-39d7-40fd-b1c4-379940a963c5
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.articlenumber16
local.journal.numberofpages17
local.journal.quartileQ2
oaire.citation.issue2
oaire.citation.titleJOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
oaire.citation.volume31
relation.isAuthorOfPublication5ba0a0e0-ebae-43a6-855c-0aabb90021f4
relation.isAuthorOfPublication.latestForDiscovery5ba0a0e0-ebae-43a6-855c-0aabb90021f4

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