Publication:
The comparative effects of local anaesthetics on wound healing in rats: Bupivacaine vs Levobupivacaine

Simple item page
dc.contributor.authorBOZKURT, SÜHEYLA
dc.contributor.authorsAtalay Y.O., Umuroglu T., Yagmur C., Gogus F.Y., Bozkurt S.
dc.date.accessioned2022-03-15T02:11:35Z
dc.date.available2022-03-15T02:11:35Z
dc.date.issued2016
dc.description.abstractThe aim of this study is to investigate the effects of local anaesthetic agents (bupivacaine and levobupivacaine) on wound healing in rats. Wistar albino rats were randomly assigned to three groups (n=10 per group); the control group, the bupivacaine group, and the levobupivacaine group. An incision measuring 5 cm in length was made over the dorsum in all groups. The incisions were infiltrated with 3 ml of normal saline in the control group, 3 ml of 0.25%bupivacaine in the bupivacaine group, and 3 ml of 0.25%levobupivacaine in the levobupivacaine group. Histopathological examinations and tensile strength measurements were performed on tissue samples taken from the incision line 14 days after infiltration. Epidermal and dermal regeneration scores were significantly lower in the levobupivacaine group compared with the bupivacaine and control groups (p<0.05). Granulation tissue thickness, angiogenesis, and tensile strength measurements were not significantly different between groups. Even though incomplete epidermal and dermal regeneration scores were attained using levobupivacaine, both bupivacaine and levobupivacaine had no negative effects on the overall clinical wound-healing process. © 2016 OMU.
dc.identifier.doi10.5835/jecm.omu.33.02.008
dc.identifier.issn13094483
dc.identifier.urihttps://hdl.handle.net/11424/247680
dc.language.isoeng
dc.publisherOndokuz Mayis Universitesi
dc.relation.ispartofJournal of Experimental and Clinical Medicine (Turkey)
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBupivacaine
dc.subjectInfiltration anaesthesia
dc.subjectLevobupivacaine
dc.subjectLocal anaesthetics
dc.subjectWound healing
dc.titleThe comparative effects of local anaesthetics on wound healing in rats: Bupivacaine vs Levobupivacaine
dc.typearticle
dspace.entity.typePublication
local.avesis.idbc01d3ea-e615-41b2-a326-a92bb526261f
local.import.packageSS21
local.import.sourceScopus
local.indexed.atSCOPUS
local.indexed.atTRDIZIN
oaire.citation.endPage98
oaire.citation.issue2
oaire.citation.startPage93
oaire.citation.titleJournal of Experimental and Clinical Medicine (Turkey)
oaire.citation.volume33
relation.isAuthorOfPublicationdd039cf9-dfb8-4af0-b879-0b88c3a852fa
relation.isAuthorOfPublication.latestForDiscoverydd039cf9-dfb8-4af0-b879-0b88c3a852fa

Files

Collections

Research Outputs