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Endobronchial ultrasound-guided cryobiopsies in peripheral pulmonary Lesions: a feasibility study

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dc.contributor.authorBOSTANCI, KORKUT
dc.contributor.authorsSchuhmann, Maren; Bostanci, Korkut; Bugalho, Antonio; Warth, Arne; Schnabel, Philipp A.; Herth, Felix J. F.; Eberhardt, Ralf
dc.date.accessioned2022-03-14T10:59:54Z
dc.date.available2022-03-14T10:59:54Z
dc.date.issued2014-01-01
dc.description.abstractPeripheral lung lesions are sometimes difficult to reach even with endobronchial ultrasound (EBUS) and insufficient material is often obtained by transbronchial forceps biopsy. Cryoprobes can be used for performing tissue biopsies. We evaluated the safety and feasibility of the cryoprobe in combination with EBUS for the diagnosis of peripheral lung lesion. Patients with peripheral lung lesions of up to 4 cm were enrolled. After identifying the lung lesion by radial EBUS, forceps biopsies and cryobiopsies were performed in a randomised order. We evaluated safety and feasibility,, and compared diagnostic yield and sample size. 39 patients were randomised and the peripheral lung lesion was reached in 31. The overall diagnostic yield was 60.5% and, in the lesions reached by EBUS, it was 74.2%. In 19 cases, the diagnosis was made with forceps as well as cryobiopsy and, in four cases, only with cryobiopsy. Cryobiopsies were significantly larger than forceps biopsies (11.17 mm(2) versus 4.69 mm(2), p<0.001). We observed one case of moderate bleeding. Transbronchial cryobiopsy with EBUS guidance is safe and useful to obtain histological samples. Larger tissue samples can be obtained by cryoprobe.
dc.identifier.doi10.1183/09031936.00011313
dc.identifier.eissn1399-3003
dc.identifier.issn0903-1936
dc.identifier.pubmed23900983
dc.identifier.urihttps://hdl.handle.net/11424/245675
dc.identifier.wosWOS:000329552200029
dc.language.isoeng
dc.publisherEUROPEAN RESPIRATORY SOC JOURNALS LTD
dc.relation.ispartofEUROPEAN RESPIRATORY JOURNAL
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectLUNG-CANCER
dc.subjectDIAGNOSTIC YIELD
dc.subjectBIOPSY
dc.subjectULTRASONOGRAPHY
dc.subjectSHEATH
dc.subjectTRIAL
dc.subjectINCREASES
dc.subjectNODULE
dc.subjectMETAANALYSIS
dc.subjectMANAGEMENT
dc.titleEndobronchial ultrasound-guided cryobiopsies in peripheral pulmonary Lesions: a feasibility study
dc.typearticle
dspace.entity.typePublication
local.avesis.idf6a7a5c4-a6ff-46a0-978d-d453488de4a0
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages7
oaire.citation.endPage239
oaire.citation.issue1
oaire.citation.startPage233
oaire.citation.titleEUROPEAN RESPIRATORY JOURNAL
oaire.citation.volume43
relation.isAuthorOfPublicationf2544aac-ac35-4e72-b6bc-4abedf96e5e3
relation.isAuthorOfPublication.latestForDiscoveryf2544aac-ac35-4e72-b6bc-4abedf96e5e3

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