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The histomorphological findings of kidneys after application of high dose and high-energy shock wave lithotripsy

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dc.contributor.authorBOZKURT, SÜHEYLA
dc.contributor.authorsDemir, Aslan; Turker, Polat; Bozkurt, Suheyla Uyar; Ilker, Yalcin Nazmi
dc.date.accessioned2022-03-12T20:26:41Z
dc.date.available2022-03-12T20:26:41Z
dc.date.issued2015
dc.description.abstractIntroduction In this animal study, we reviewed the histomorphological findings in rabbit kidneys after a high number of high-energy shock wave applications and observed if there were any cumulative effects after repeated sessions. Material and methods We formed 2 groups, each consisting of 8 rabbits. Group 1 received 1 session and group 2 received 3 sessions of ESWL with a 7 day interval between sessions, consisting of 3500 beats to the left kidney and 5500 beats to the right kidney per session. The specimens of kidneys were examined histomorphologically after bilateral nephrectomy was performed. For statistical analysis, 4 groups of specimens were formed. The first and second groups received 1 session, 3500 and 5500 beats, respectively. The third and fourth groups received 3 sessions, at 3500 and 5500 beats per each session, respectively. The sections were evaluated under a light microscope to determine subcapsular thickening; subcapsular, intratubular and parenchymal hemorrhage; subcapsular, intersitital, perivascular and proximal ureteral fibrosis; paranchymal necrosis; tubular epithelial vacuolization; tubular atrophy; glomerular destruction and calcification. Results In histopathological examinations capsular thickening, subcapsular hematoma, tubuloepithelial vacuolisation, glomerular destruction, parenchymal hemorrhage, interstitial fibrosis, and perivascular fibrosis were observed in all groups. In statistical analysis, on the basis of perivascular fibrosis and tubular atrophy, there was a beats per session dependent increase of both. Conclusions The detrimental effects from ESWL are dose dependent but not cumulative for up to 3 sessions. Histopathological experimental animal studies will aid in understanding local and maybe, by means of these local effects, systemic effects.
dc.identifier.doi10.5173/ceju.2015.01.480
dc.identifier.eissn2080-4873
dc.identifier.issn2080-4806
dc.identifier.pubmed25914842
dc.identifier.urihttps://hdl.handle.net/11424/233523
dc.identifier.wosWOS:000362068300015
dc.language.isoeng
dc.publisherPOLISH UROLOGICAL ASSOC
dc.relation.ispartofCENTRAL EUROPEAN JOURNAL OF UROLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectESWL (extracorporeal shock wave lithotripsy)
dc.subjecthigh-energy shock waves
dc.subjecthistopathology
dc.subjectkidney
dc.subjectRABBIT KIDNEY
dc.subjectRENAL INJURY
dc.subjectDAMAGE
dc.subjectMODEL
dc.subjectESWL
dc.titleThe histomorphological findings of kidneys after application of high dose and high-energy shock wave lithotripsy
dc.typearticle
dspace.entity.typePublication
local.avesis.id3071d6c7-fb6b-4b1a-b444-6a6d96cb76e4
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages7
oaire.citation.endPage78
oaire.citation.issue1
oaire.citation.startPage72
oaire.citation.titleCENTRAL EUROPEAN JOURNAL OF UROLOGY
oaire.citation.volume68
relation.isAuthorOfPublicationdd039cf9-dfb8-4af0-b879-0b88c3a852fa
relation.isAuthorOfPublication.latestForDiscoverydd039cf9-dfb8-4af0-b879-0b88c3a852fa

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