Publication: Antimicrobial effects of stinging nettle (urtica dioica L.) extracts on campylobacter jejuni
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Date
2021-03-28
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Abstract
Stinging nettle (Urticadioica L.) is a perennial plant from the Urticaceae family, whose leaves
and stem are covered with irritating hairs. It grows wild in Europe, North America, North Africa
and West Asia and in every region of our country. U. dioica; regard to its rich nutritional value
and essential oils, phenolic compounds and flavonoids, has been used both as a food and
traditionally for healing since years. Campylobacter jejuni is a gram-negative bacterium that
causes infections especially in poultry meat, meat products, raw milk, contaminated water, and
foodborne infections. It is a common cause of diarrhea cases in developing countries and sporadic
gastroenteritis in developed countries around the world. C. jejuni produces adenylate cyclase
activating toxin, causing "campylobacter gastroenteritis". It is also a notable pathogen in terms of
infection control, due to its association with severe neuropathological sequelae such as, GuillainBarré, Reiter syndromes, and cases of bacteremia. C. jejuni, which can rapidly develop resistance
to antibiotics used for infection control, poses a global risk to human health and increases the
need for the development of antimicrobials with different mechanisms of action.In today's
agriculture and food industry, natural and safe antimicrobials are needed with the widespread use
of antibacterials and increased bacterial resistance to existing antibiotics for the control of
microorganisms that pose a global health risk in the medical field. For this reason, U. dioica is
often under investigation for its antimicrobial effects. In the literature, extracts of U. dioica
against food-borne Campylobacter jejuni, Pseudomonas, Shigella spp., Bacillus cereus,
Staphylococcus aureus, Vibrio parahaemolyticus, and Escherichia coli; hospital acquired,
Staphylococcus aureus, Bacillus subtilis, Salmonella spp. and there are data showing
antimicrobial activity on methicillin-resistant Staphylococcus auerus (MRSA). In disk diffusion
analysis, it was found that U. dioica ethanolic extract exhibited antimicrobial effects on C. jejuni.
It has been determined that tinctures of U. dioica have a minimum inhibitory concentration of
3.125% against C. jejuni. By using U. dioica extract as a strategy to combat infections, it seems
to be important revealing its potential of inhibition
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Keywords
Urtica dioica, nettle, antimicrobial agents, Campylobacter jejuni
Citation
Aydın H. B., OMURTAG KORKMAZ B. İ., \"Antimicrobial Effects of Stinging Nettle (Urtica dioica L.) Extracts on Campylobacter jejuni\", International Congress on Biological and Health Sciences, Türkiye, 26 Şubat 2021, ss.381