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Investigation of the protective effect of gel incorporating Eugenia jambolana leaf extract on 5-fluorouracil-induced oral mucositis: an animal study

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dc.contributor.authorBİNGÖL ÖZAKPINAR, ÖZLEM
dc.contributor.authorARICIOĞLU, FEYZA
dc.contributor.authorsAKSOY N., Sen E., Sukmasari S., BİNGÖL ÖZAKPINAR Ö., ARICIOĞLU F., YÜCEL Y. Y., Dumlu M. R., Doolaanea A. A., AbdulRahman M. N., OLGAÇ N. V., et al.
dc.date.accessioned2023-07-10T08:57:03Z
dc.date.available2023-07-10T08:57:03Z
dc.date.issued2022-08-01
dc.description.abstractPurpose The study aimed to evaluate the possible preventive effect of two concentrations (3 and 5% w/w) of Eugenia jambolana (EJ) extract against 5-FU-induced mucositis. Method Sixteen adult rats were separated into four groups: two control and two preventive groups. Animals in Groups 1, 2, and 3 were injected intraperitoneally with 60 mg/kg/day of 5-FU on Day 1 followed by 150 mg/kg/day on Day 5. The rats in Group 4 (negative control) were given physiological saline at the same times and doses. Furthermore, on the fifth day of the study, the cheek and sublingual mucosa were irritated by external superficial scratches using the tip of an 18-G needle, followed by the application 15 mu L of 20% acetic acid, after which 3 and 5% EJ w/w gels were applied topically for animals in Groups 2 and 3, respectively. Results The weight and the mucositis scores were recorded. Antioxidant and anti-inflammatory markers and biochemical tests were analyzed. Significant differences were found between the study groups in weight loss, clinical mucositis scores, mortality rates, and antioxidant and anti-inflammatory parameters. Conclusion The preventive effect of 3% gel was significant, with no mortality rate, making it an option for preventive strategies.
dc.identifier.citationAKSOY N., Sen E., Sukmasari S., BİNGÖL ÖZAKPINAR Ö., ARICIOĞLU F., YÜCEL Y. Y., Dumlu M. R., Doolaanea A. A., AbdulRahman M. N., OLGAÇ N. V., et al., "Investigation of the protective effect of gel incorporating Eugenia jambolana leaf extract on 5-fluorouracil-induced oral mucositis: an animal study", JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, cilt.148, sa.8, ss.2153-2162, 2022
dc.identifier.doi10.1007/s00432-022-04065-3
dc.identifier.endpage2162
dc.identifier.issn0171-5216
dc.identifier.issue8
dc.identifier.startpage2153
dc.identifier.urihttps://hdl.handle.net/11424/290958
dc.identifier.volume148
dc.language.isoeng
dc.relation.ispartofJOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectOnkoloji
dc.subjectMedicine
dc.subjectHealth Sciences
dc.subjectInternal Medicine Sciences
dc.subjectInternal Diseases
dc.subjectOncology
dc.subjectONKOLOJİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectONCOLOGY
dc.subjectCLINICAL MEDICINE
dc.subjectClinical Medicine (MED)
dc.subjectMucositis
dc.subjectChemotherapy
dc.subjectEugenia jambolana
dc.subjectAntioxidant
dc.subjectAnti-inflammatory
dc.subjectGel
dc.subjectNF-KAPPA-B
dc.subjectOXIDATIVE STRESS
dc.subjectINTERLEUKIN-10
dc.subjectCHEMOTHERAPY
dc.subjectMANAGEMENT
dc.subjectPLASMA
dc.titleInvestigation of the protective effect of gel incorporating Eugenia jambolana leaf extract on 5-fluorouracil-induced oral mucositis: an animal study
dc.typearticle
dspace.entity.typePublication
local.avesis.id71a7be02-b65e-40cd-97b3-710f78d27e63
local.indexed.atWOS
local.indexed.atPUBMED
local.indexed.atSCOPUS
relation.isAuthorOfPublication44b61e5d-4045-4d63-926e-2f01c3ee5642
relation.isAuthorOfPublicationa3c22d37-3fc1-4221-b0b3-ac9764a7b8b3
relation.isAuthorOfPublication.latestForDiscovery44b61e5d-4045-4d63-926e-2f01c3ee5642

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