Publication: 5-Flourouracil-Induced Encephalopathy in Parkinson's Disease
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Date
2012-03-31
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AKAD DOKTORLAR YAYINEVI
Abstract
A 59 year-old male with Parkinson's disease developed encephalopathy during adjuvant treatment of rectal cancer. Acute neurotoxicity related to high dose 5-Flourouracil infusion is well described, but encephalopathy with low dose bolus 5-Flourouracil is rare. The advanced Parkinson's disease patients may be more prone to hyperammonemia associated encephalopathy caused by 5-Flourouracil. The prompt recognition of the symptoms is key to diagnosis and treatment.
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Keywords
Parkinson's disease, 5-Flourouracil, Rectum cancer, Encephalopathy, NEUROTOXICITY, 5-FLUOROURACIL, FLUOROURACIL, INFUSION