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The Distribution of Different Types of Diabetes in Childhood: A Single Center Experience

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dc.contributor.authorBEREKET, ABDULLAH
dc.contributor.authorsHaliloglu, Belma; Abali, Saygin; Bugrul, Fuat; Celik, Enes; Bas, Serpil; Atay, Zeynep; Guran, Tulay; Turan, Serap; Bereket, Abdullah
dc.date.accessioned2022-03-14T09:03:33Z
dc.date.available2022-03-14T09:03:33Z
dc.date.issued2018-05-18
dc.description.abstractObjective: Type I diabetes (T1D) is the most common cause of diabetes in childhood but type 2 diabetes (T2D) and maturity onset diabetes of the young (MODY) are emerging as noteworthy causes of diabetes at young ages. The aim is to determine the distribution, trends and clinical features of the different types of diabetes in childhood in one tertiary center. Methods: The records of children and adolescents aged 0-18 years who were diagnosed as diabetes/persistent hyperglycemia between January 1999 and December 2016, were reviewed. Clinical and laboratory characteristics of the patients at diagnosis and type of diabetes were recorded. Results: The mean +/- standard deviation age of 835 patients (48.7% females) at diagnosis was 8.8 +/- 4.4 years. Eighty-four percent of the patients were diagnosed as T1D, 5.7% as T2D, 5.3% as clinical MODY and 5% as being cases of other types of diabetes. The frequency of diabetic ketoacidosis (DKA) and severe DKA in T1D were 48.4% and 11.6%, respectively. Fourteen patients (29.2 %) with T2D presented with ketosis and two of them (4.2 %) had DKA at diagnosis. Antibody positivity was 83.1 % in T1D and 14.8% in T2D. A statistically significant increase in the frequency of T2D has clearly been demonstrated in recent years with a frequency of 1.9%, 2.4% and 7.9% in 1999-2004, 2005-2010 and 2011-2016, respectively (p <0.001). In MODY, genetic analysis was performed in 26 (59%) patients and NNF1A and GCK gene mutations were detected in 3 (11.5%) and 14 (53.8%) patients, respectively. Conclusion: Although the most frequent cause of DM is T1D in childhood, a trend towards increase in the frequency of T2D in recent years is notable in our population.
dc.identifier.doi10.4274/jcrpe.5204
dc.identifier.eissn1308-5735
dc.identifier.issn1308-5727
dc.identifier.pubmed29175806
dc.identifier.urihttps://hdl.handle.net/11424/242293
dc.identifier.wosWOS:000432911500006
dc.language.isoeng
dc.publisherGALENOS YAYINCILIK
dc.relation.ispartofJOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectType 1 diabetes
dc.subjecttype 2 diabetes
dc.subjectMODY
dc.subjectchildhood
dc.subjectPOLISH CHILDREN
dc.subjectONSET
dc.subjectPREVALENCE
dc.subjectDIAGNOSIS
dc.subjectMELLITUS
dc.subjectTURKEY
dc.subjectYOUNG
dc.subjectADOLESCENTS
dc.subjectREGISTRY
dc.subjectPROGRAM
dc.titleThe Distribution of Different Types of Diabetes in Childhood: A Single Center Experience
dc.typearticle
dspace.entity.typePublication
local.avesis.id7ee4ebc3-037e-4c70-8f59-af7a933b286c
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.indexed.atTRDIZIN
local.journal.numberofpages6
local.journal.quartileQ3
oaire.citation.endPage130
oaire.citation.issue2
oaire.citation.startPage125
oaire.citation.titleJOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY
oaire.citation.volume10
relation.isAuthorOfPublication669e9474-4e39-453f-a4bc-4ede9cb5abac
relation.isAuthorOfPublication.latestForDiscovery669e9474-4e39-453f-a4bc-4ede9cb5abac

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