Publication:
Estrogen Protects against Oxidative Multiorgan Damage in Rats with Chronic Renal Failure

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dc.contributor.authorYEGEN, BERRAK
dc.contributor.authorsKasimay, Oezguer; Sener, Goeksel; Cakir, Baris; Yueksel, Meral; Cetinel, Sule; Contuk, Gazi; Yegen, Berrak C.
dc.date.accessioned2022-03-12T17:37:15Z
dc.date.available2022-03-12T17:37:15Z
dc.date.issued2009
dc.description.abstractThe impact of sex dimorphism on chronic renal failure (CRF)-induced oxidative multiorgan damage and the effects of estradiol (E-2) loss and E-2 supplementation on the progress of CRF were studied. Sprague-Dawley rats underwent 5/6 nephrectomy (CRF), and a group of female rats had bilateral ovariectomy (OVX), while the sham-operated rats had no nephrectomy or OVX. Rats received either estradiol propionate (50 mu g/kg/day) or vehicle for six weeks. Serum BUN levels were elevated in both male and female CRF groups treated with vehicle, while creatinine level was not significantly changed in the female CRF group. CRF-induced elevation in serum TNF-alpha of male rats was abolished when the animals were treated with E-2, while OVX exaggerated TNF-alpha response. In OVX and male rats with CRF, E-2 treatment reversed the malondialdehyde elevations in all the studied tissues (kidney, heart, lung, ileum, brain, liver, and gastrocnemius muscle), while depletion of glutathione in these tissues was prevented by E-2 treatment. Similarly, increased levels of myeloperoxidase activity, lucigenin chemiluminescence, and collagen in most of the tissues were reversed by E-2 treatment. The findings show that the extent of tissue injuries was relatively less in females, while ovariectomy exacerbated all the indices of oxidative injury. Moreover, the administration of E-2, with its potent anti-oxidant and anti-inflammatory effects, markedly improved CRF-induced systemic inflammatory outcomes in both male and female rats by depressing tissue neutrophil infiltration and modulating the release of inflammatory cytokines.
dc.identifier.doi10.3109/08860220903134563
dc.identifier.eissn1525-6049
dc.identifier.issn0886-022X
dc.identifier.pubmed19814639
dc.identifier.urihttps://hdl.handle.net/11424/229361
dc.identifier.wosWOS:000271015200013
dc.language.isoeng
dc.publisherTAYLOR & FRANCIS LTD
dc.relation.ispartofRENAL FAILURE
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectestradiol
dc.subjectchronic renal failure
dc.subjectTNF-alpha
dc.subjectmyeloperoxidase
dc.subjectlipid peroxidation
dc.subjectISCHEMIA-REPERFUSION INJURY
dc.subjectNITRIC-OXIDE SYNTHASE
dc.subject17-BETA-ESTRADIOL SUPPLEMENTATION
dc.subjectHEMODIALYSIS-PATIENTS
dc.subjectANTIOXIDANT SYSTEM
dc.subjectSEXUAL-DIMORPHISM
dc.subjectBLOOD-PRESSURE
dc.subjectIN-VITRO
dc.subjectSTRESS
dc.subjectDISEASE
dc.titleEstrogen Protects against Oxidative Multiorgan Damage in Rats with Chronic Renal Failure
dc.typearticle
dspace.entity.typePublication
local.avesis.id860e8b77-e5f7-45c1-a11d-e8c11e2da583
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages15
oaire.citation.endPage725
oaire.citation.issue8
oaire.citation.startPage711
oaire.citation.titleRENAL FAILURE
oaire.citation.volume31
relation.isAuthorOfPublicatione4eaf9ac-f8dc-4e2b-b940-895cc906790d
relation.isAuthorOfPublication.latestForDiscoverye4eaf9ac-f8dc-4e2b-b940-895cc906790d

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