Publication:
Plasma concentration-time profile of a single dose of enteric-coated omeprazole in male and female healthy volunteers

Simple item page
dc.contributor.authorGÖREN, MEHMET ZAFER
dc.contributor.authorAKIN, ŞEHNAZ
dc.contributor.authorGÜLHAN, REZZAN
dc.contributor.authorONAT, FİLİZ
dc.contributor.authorsIskender E., ASLAN N., GÖREN M. Z., Tellioglu T., Akin S., Erin N., GÜLHAN R., ONAT F., Berkman K., Oktay S.
dc.date.accessioned2023-06-01T07:08:58Z
dc.date.available2023-06-01T07:08:58Z
dc.date.issued2000-01-01
dc.description.abstractO b je c tiv e : T h e b io a vaila b ility of a single dose (20 m g) o f tw o e n te ric -c o a te d o m e p ra z o le fo rm u la tio n s, m arketed in T urkey, given 10-15 m in b e fo re b reakfast, w as studied in 12 healthy vo lu n te e rs (6 m ales and 6 fem ales) in a d o u b le ­ blind, cro s s o v e r design. M e th o d s : B lood sam ples w ere collected prior to and at 10 tim e points w ithin 12 hrs. after dosing. P la s m a o m e p ra z o le c o n c e n tra tio n s w e re m easured by H P LC te ch n iq u e in our laboratory. R e s u lts a n d C o n c lu s io n s : T he tw o products w ere found to be b io e q u iva le n t in term s of extent of a b s o rp tio n (th e a re a u n d e r the p la s m a c o n c e n tra tio n -tim e cu rve s). M u ltip e a k p la sm a co n ce n tra tio n pro file s w e re seen in m ost of the su b je cts w ith both products. T im e to the e a rlie r peaks w as 1-2 hrs. and those peaks w ere low er in a m p litu d e th a n th e p e a ks re a ch e d a p p ro x im a te ly 4 .5 hrs. a fte r the a p p lica tio n . In te re stin g ly, the m u ltip e a k profile w as m ore fre q u e n t and the e a rlie r peaks w ere sig nificantly higher in fe m a le su b je cts than in m ales. The reason fo r th is g e n d e r d iffe re n ce in m ultipeak p la s m a c o n c e n tra tio n - tim e p ro file of oral o m e p ra zo le needs fu rth e r investigation.
dc.identifier.citationIskender E., ASLAN N., GÖREN M. Z., Tellioglu T., Akin S., Erin N., GÜLHAN R., ONAT F., Berkman K., Oktay S., "Plasma concentration-time profile of a single dose of enteric-coated omeprazole in male and female healthy volunteers", Marmara Medical Journal, cilt.13, sa.3, ss.127-130, 2000
dc.identifier.endpage130
dc.identifier.issn1019-1941
dc.identifier.issue3
dc.identifier.startpage127
dc.identifier.urihttps://dergipark.org.tr/tr/download/article-file/252734
dc.identifier.urihttps://hdl.handle.net/11424/289825
dc.identifier.volume13
dc.language.isoeng
dc.relation.ispartofMarmara Medical Journal
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectMedicine
dc.subjectHealth Sciences
dc.subjectFundamental Medical Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectTIP, GENEL & DAHİLİ
dc.subjectClinical Medicine (MED)
dc.subjectCLINICAL MEDICINE
dc.subjectMEDICINE, GENERAL & INTERNAL
dc.subjectGenel Tıp
dc.subjectGeneral Medicine
dc.subjectBioavailability
dc.subjectCoated capsules
dc.subjectEnteric
dc.subjectGender difference
dc.subjectOmeprazole
dc.subjectOmeprazole
dc.subjectBioavailability
dc.subjectEnteric
dc.subjectcoated capsules
dc.subjectGender difference
dc.titlePlasma concentration-time profile of a single dose of enteric-coated omeprazole in male and female healthy volunteers
dc.typearticle
dspace.entity.typePublication
local.avesis.idf2aa5863-88b1-49c2-b2d2-21337af8a86f
local.indexed.atSCOPUS
local.indexed.atTRDIZIN
relation.isAuthorOfPublicationf91c1cf5-3919-48eb-a772-35abafdc304e
relation.isAuthorOfPublication8557a921-9e48-4044-8586-c133b8153c4f
relation.isAuthorOfPublicationc44fef14-869d-4c28-a766-5e080b17c687
relation.isAuthorOfPublicationc359dea3-046f-4397-90d5-62e4bfc31869
relation.isAuthorOfPublication.latestForDiscoveryf91c1cf5-3919-48eb-a772-35abafdc304e

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
4.pdf
Size:
356.29 KB
Format:
Adobe Portable Document Format
Download

Collections

Research Outputs