Publication:
The effects of resveratrol treatment on caveolin-3 expression and Na+/K+ ATPase activity in rats with isoproterenol-induced myocardial injury

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dc.contributor.authorYEGEN, BERRAK
dc.contributor.authorsSehirli, Ahmet Ozer; Aykac, Asli; Tetik, Sermin; Yiginer, Omer; Cetinel, Sule; Ozkan, Naziye; Akkiprik, Mustafa; Kaya, Zehra; Yegen, Berrak Caglayan; Tezcan, Mehmet; Sener, Goeksel
dc.date.accessioned2022-03-12T04:22:49Z
dc.date.available2022-03-12T04:22:49Z
dc.date.issued2020
dc.description.abstractOBJECTIVE: The present study aims to investigate the therapeutic effects of resveratrol (RES) on isoproterenol (ISO) induced myocardial injury rat model. METHODS: Catecholamine-induced heart damage was induced by ISO treatment for 30 days. The rats were divided into four groups as follows: the control group received saline, the ISO group received 5.0 mg/kg ISO, the RES group received 10 mg/kg RES, and the ISO-RES group received 10 mg/kg RES and 5 mg/kg ISO treatments for 30 days. Following echocardiographic measurements and body weight recorded, the rats were decapitated. Plasma and cardiac tissue samples obtained by decapitation were analyzed using biochemical, histopathological, molecular and immunohistochemical methods. RESULTS: In the ISO group, Na+/K+ ATPase activity and ATP content, GSH, and caveolin-3 levels were low. LDH, CK and lysosomal enzyme activities, MDA level, and MPO activity were found to be high. It was determined that GSH and MDA levels and MPO, Na+/K+ ATPase activity, ATP content caveolin-3 levels changes that arose from ISO treatment were suppressed by RES treatment. CONCLUSION: RES treatment has ameliorated all the functional and biochemical parameters. The results obtained in this study suggest that RES is a promising supplement against catecholamine exposure as it improves antioxidant defense mechanisms in the heart. In the light of above-mentioned data, RES can be assumed as a promising agent in ameliorating the oxidative injury of the myocardium.
dc.identifier.doi10.14744/nci.2020.97957
dc.identifier.issn2148-4902
dc.identifier.pubmed33043254
dc.identifier.urihttps://hdl.handle.net/11424/223848
dc.identifier.wosWOS:000564196700001
dc.language.isoeng
dc.publisherKARE PUBL
dc.relation.ispartofNORTHERN CLINICS OF ISTANBUL
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCaveolin-3
dc.subjectheart failure
dc.subjectisoproterenol
dc.subjectlysosomal enzymes
dc.subjectresveratrol
dc.subjectINDUCED CARDIOTOXICITY
dc.subjectHEART
dc.subjectACID
dc.subjectINFARCTION
dc.subjectPROTECTS
dc.subjectNECROSIS
dc.subjectMYELOPEROXIDASE
dc.subjectMECHANISMS
dc.titleThe effects of resveratrol treatment on caveolin-3 expression and Na+/K+ ATPase activity in rats with isoproterenol-induced myocardial injury
dc.typeconferenceObject
dspace.entity.typePublication
local.avesis.idafa5283f-db39-4442-aa41-731915ed8827
local.conference.dateMAR 26-29, 2015
local.conference.locationIstanbul, TURKEY
local.conference.title11th International Congress of Update in Cardiology and Cardiovascular Surgery
local.import.packageSS14
local.indexed.atWOS
local.indexed.atPUBMED
local.indexed.atTRDIZIN
local.journal.numberofpages8
oaire.citation.endPage320
oaire.citation.issue4
oaire.citation.startPage313
oaire.citation.titleNORTHERN CLINICS OF ISTANBUL
oaire.citation.volume7
relation.isAuthorOfPublicatione4eaf9ac-f8dc-4e2b-b940-895cc906790d
relation.isAuthorOfPublication.latestForDiscoverye4eaf9ac-f8dc-4e2b-b940-895cc906790d

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