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Baseline carotid intima-media thickness is associated with cardiovascular morbidity and mortality in peritoneal dialysis patients

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dc.contributor.authorVELİOĞLU, ARZU
dc.contributor.authorsAsicioglu, Ebru; Velioglu, Arzu; Arikan, Hakki; Koc, Mehmet; Tuglular, Serhan; Ozener, Cetin
dc.date.accessioned2022-03-12T22:55:17Z
dc.date.available2022-03-12T22:55:17Z
dc.date.issued2021
dc.description.abstractCarotid intima-media thickness (CIMT) is an early marker of atherosclerosis and is increased in peritoneal dialysis (PD) patients. Association of CIMT with cardiovascular disease (CVD) or mortality is less clear. Fibroblast growth factor-23 (FGF-23) is a hormone associated with vascular calcification, atherosclerosis, and mortality in the hemodialysis population. We investigated whether baseline CIMT and FGF-23 are associated with CVD and mortality in PD patients. Fifty-five PD patients were included. CVD was defined as ischemic heart disease, stroke, or peripheral artery disease. Intact FGF-23 was measured in plasma. CIMT was measured by ultrasonography. Twenty-one patients developed CVD and 12 died over 47.1 +/- 33.8 months. Patients with CVD were older (55.9 +/- 10.5 vs. 42.5 +/- 12.9 years, P < .01), had lower albumin (3.8 +/- 0.5 vs. 4.2 +/- 0.3 g/dL, P < .01) and higher CIMT (0.87 +/- 0.22 vs. 0.61 +/- 0.11 mm, P < .01). Patients with mortality were also older (53.5 +/- 11.5 vs. 45.8 +/- 13.8 years, P = .05), had lower albumin (3.7 +/- 0.6 vs. 4.1 +/- 0.3 g/dL, P < .01), higher CRP (15.0 +/- 8.5 vs. 7.6 +/- 8.4 mg/L, P < .01) and CIMT (0.9 +/- 0.3 vs. 0.6 +/- 0.1 mm, P < .01). Albumin and CIMT were associated with CVD and CIMT > 0.75 mm was associated with cardiovascular mortality. FGF-23 did not show any correlations. CIMT at baseline is associated with CVD and mortality in PD patients.
dc.identifier.doi10.1111/1744-9987.13629
dc.identifier.eissn1744-9987
dc.identifier.issn1744-9979
dc.identifier.pubmed33511768
dc.identifier.urihttps://hdl.handle.net/11424/236703
dc.identifier.wosWOS:000629277200001
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofTHERAPEUTIC APHERESIS AND DIALYSIS
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectcardiovascular disease
dc.subjectcardiovascular mortality
dc.subjectcarotid intima&#8208
dc.subjectmedia thickness
dc.subjectfibroblast growth factor 23
dc.subjectperitoneal dialysis
dc.titleBaseline carotid intima-media thickness is associated with cardiovascular morbidity and mortality in peritoneal dialysis patients
dc.typearticle
dspace.entity.typePublication
local.avesis.id87816b1c-239f-4b7e-8fdd-28bcb454a94d
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages8
oaire.citation.endPage969
oaire.citation.issue6
oaire.citation.startPage962
oaire.citation.titleTHERAPEUTIC APHERESIS AND DIALYSIS
oaire.citation.volume25
relation.isAuthorOfPublicationa7410f0e-0eb4-4b83-ad61-a71dfbee164f
relation.isAuthorOfPublication.latestForDiscoverya7410f0e-0eb4-4b83-ad61-a71dfbee164f

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