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Effect of topically applied hyaluronic acid on pain and palatal epithelial wound healing: An examiner-masked, randomized, controlled clinical trial

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dc.contributor.authorDOĞAN, BAŞAK
dc.contributor.authorsYildirim, Selin; Ozener, Hafize Ozturk; Dogan, Basak; Kuru, Bahar
dc.date.accessioned2022-03-12T22:26:01Z
dc.date.available2022-03-12T22:26:01Z
dc.date.issued2018
dc.description.abstractBackground: This study aims to evaluate the effects of two different concentrations of topical hyaluronic acid (HA) on postoperative patient discomfort and wound healing of palatal donor sites after free gingival graft (FGG) surgery. Methods: Thirty-six patients requiring FGG were randomly assigned into three groups in an examiner-masked, randomized, controlled clinical trial. After harvesting palatal grafts, 0.2% and 0.8% HA gels were used in test groups 1 and 2, respectively. Gels were applied on donor sites and protected with periodontal dressing in the test groups, whereas the wound was covered only with periodontal dressing in the control group. On days 3, 7, 14, and 21, pain and burning sensation were recorded using a visual analog scale (VAS) as well as other parameters such as complete epithelization (CE) and color match on days 3, 7, 14, 21, and 42. Results: Test groups experienced less pain than the control group on days 3 and 7 (P < 0.001 and P < 0.001, respectively). Mean VAS score for burning sensation was higher in the control group on day 3 compared with test groups 1 and 2 (P = 0.03 and P = 0.02, respectively). CE in all patients was achieved on day 21 in both test groups, whereas it was achieved on day 42 in the control group. The test groups showed higher color match scores than the control group on days 21 (P < 0.001 and P < 0.001, respectively) and 42 (P = 0.004 and P = 0.002, respectively). Conclusion: Topical application of HA exhibits positive impact on postoperative pain and burning sensation, and accelerates palatal wound healing in terms of epithelization and color match.
dc.identifier.doi10.1902/jop.2017.170105
dc.identifier.eissn1943-3670
dc.identifier.issn0022-3492
dc.identifier.pubmed28914592
dc.identifier.urihttps://hdl.handle.net/11424/235003
dc.identifier.wosWOS:000424513500004
dc.language.isoeng
dc.publisherAMER ACAD PERIODONTOLOGY
dc.relation.ispartofJOURNAL OF PERIODONTOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectoperative
dc.subjectpain
dc.subjectpostoperative complications
dc.subjectsurgical procedures
dc.subjecttransplants
dc.subjectwound healing
dc.subjectSUBEPITHELIAL CONNECTIVE-TISSUE
dc.subjectSODIUM HYALURONATE
dc.subjectDONOR SITE
dc.subjectPERIODONTAL SURGERY
dc.subjectHEMOSTATIC AGENTS
dc.subjectPATIENT MORBIDITY
dc.subjectGRAFT
dc.subjectCOVERAGE
dc.subjectEFFICACY
dc.subjectGEL
dc.titleEffect of topically applied hyaluronic acid on pain and palatal epithelial wound healing: An examiner-masked, randomized, controlled clinical trial
dc.typearticle
dspace.entity.typePublication
local.avesis.ida9edf05d-7959-40a2-8ec0-077c33f1b2d0
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages10
local.journal.quartileQ1
oaire.citation.endPage45
oaire.citation.issue1
oaire.citation.startPage36
oaire.citation.titleJOURNAL OF PERIODONTOLOGY
oaire.citation.volume89
relation.isAuthorOfPublicationa2569f78-7a2a-4f98-8cc9-d8b67ae56f6d
relation.isAuthorOfPublication.latestForDiscoverya2569f78-7a2a-4f98-8cc9-d8b67ae56f6d

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